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Transendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1.
Microbiol Spectr
December 2024
Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada.
Despite its importance in pathogenesis, the hematogenous dissemination pathway of is still largely uncharacterized. To probe the molecular details of transendothelial migration more easily, we studied this process using cultured primary or telomerase-immortalized human microvascular endothelial cells in a medium that maintains both the human cells and the spirochetes. In -infected monolayers, we observed ~55% of wild-type spirochetes crossing the monolayer.
View Article and Find Full Text PDFMolecular identification of tick (Acari: Ixodidae) and tick-borne pathogens from Przewalski's gazelle (Procapra Przewalskii) and Tibetan sheep (Ovis aries) in Qinghai Lake National Nature Reserve, China.
Heliyon
December 2024
Qinghai University State Key Laboratory of Plateau Ecology and Agriculture, Xining, 810016, Qinghai, China.
The Qinghai Lake National Nature Reserve (QLNNR), renowned for its abundant natural resources and diverse ecological habitats, serves as an ideal environment for ticks, thereby increasing the risk of various tick-borne pathogens (TBPs) transmission. This study aimed to investigate the prevalence of TBPs in ticks collected from Przewalski's gazelle and Tibetan sheep within the QLNNR. A total of 313 tick samples were collected from the vicinity of Qinghai Lake.
View Article and Find Full Text PDFA comparative study evaluating three line immunoassays available for serodiagnosis of equine Lyme borreliosis: Detection of Borrelia burgdorferi sensu lato-specific antibodies in serum samples of vaccinated and non-vaccinated horses.
PLoS One
December 2024
Faculty of Veterinary Medicine, Department of Veterinary Sciences, Institute for Infectious Diseases and Zoonoses, Chair of Bacteriology and Mycology, Ludwig-Maximilians-Universität Munich, Oberschleißheim, Bavaria, Germany.
Diagnosis of equine Lyme borreliosis (LB), an infection caused by members of the Borrelia burgdorferi sensu lato complex (Bbsl), is challenging due to the nonspecific clinical signs of the disease and due to the variety of non-standardized serological tests. Specific vaccine-induced antibodies against LB, providing an effective protection against the infection, complicate the issue further. The standard for the detection of specific antibodies against Bbsl is a two-tier test system based on an enzyme-linked immunosorbent assay (ELISA) or indirect fluorescent antibody test (IFA) for antibody screening combined with a qualitative, highly specific immunoassay (e.
View Article and Find Full Text PDFBorrelia miyamotoi and Borrelia burgdorferi sensu lato widespread in urban areas of the Czech Republic.
Parasit Vectors
December 2024
Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Palackého tř. 1946/1, 61242, Brno, Czech Republic.
Background: Borrelia miyamotoi and Borrelia burgdorferi sensu lato (s.l.) are important zoonotic agents transmitted by Ixodes ricinus ticks, which are widely distributed across Central Europe.
View Article and Find Full Text PDFThe AxBioTick study - immune gene expression signatures in human skin bitten by Borrelia-infected versus non-infected ticks.
BMC Infect Dis
December 2024
Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Background: Borrelia infection is caused by Borrelia burgdorferi sensu lato and transmitted by Ixodes ricinus ticks, a common tick-borne infection in Northern Europe. The establishment of Borrelia infection depends on transmission of the spirochetes, as well as the immune response generated in the skin after a bite. Here we aim to investigate the local immune response in the skin after a tick bite and assess the possible direct effects of Borrelia, by applying gene expression analysis of the immune response in skin exposed to Borrelia-infected and non-infected ticks, respectively.
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