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SurfR: Riding the wave of RNA-seq data with a comprehensive bioconductor package to identify surface protein-coding genes.
Bioinform Adv
December 2024
Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.
Motivation: Proteins at the cell surface connect signaling networks and largely determine a cell's capacity to communicate and interact with its environment. In particular, variations in transcriptomic profiles are often observed between healthy and diseased cells, leading to distinct sets of cell-surface proteins. For these reasons, cell-surface proteins may act as biomarkers for the detection of cells of interest in tissues or body fluids, are often the target of pharmaceutical agents, and hold significant promise in the clinical practice for diagnosis, prognosis, treatment development, and evaluation of therapy response.
View Article and Find Full Text PDFAn Eco-Driving Strategy at Multiple Fixed-Time Signalized Intersections Considering Traffic Flow Effects.
Sensors (Basel)
September 2024
Department of Mechanical and Electrical Engineering, Xiamen University, Xiamen 361005, China.
To encourage energy saving and emission reduction and improve traffic efficiency in the multiple signalized intersections area, an eco-driving strategy for connected and automated vehicles (CAVs) considering the effects of traffic flow is proposed for the mixed traffic environment. Firstly, the formation and dissipation process of signalized intersection queues are analyzed based on traffic wave theory, and a traffic flow situation estimation model is constructed, which can estimate intersection queue length and rear obstructed fleet length. Secondly, a feasible speed set calculation method for multiple signalized intersections is proposed to enable vehicles to pass through intersections without stopping and obstructing the following vehicles, adopting a trigonometric profile to generate smooth speed trajectory to ensure good riding comfort, and the speed trajectory is optimized with comprehensive consideration of fuel consumption, emissions, and traffic efficiency costs.
View Article and Find Full Text PDFAssociation of vitamin D deficiency with post-exercise hypotension and arterial stiffness following prolonged endurance exercise in healthy young men.
J Int Soc Sports Nutr
December 2024
National Chung Cheng University, Department of Athletic Sports, Chiayi, Taiwan.
Background: Vitamin D is associated with vascular function; however, the impact of different vitamin D levels on vascular elasticity following prolonged exercise remains uncertain. The primary objective of this study was to investigate the association of vitamin D levels with changes in peripheral pulse wave velocity (pPWV) and the magnitude of acute post-exercise hypotension (PEH) following prolonged endurance exercise in healthy young men.
Methods: All the participants were divided into two groups: the 25-hydroxyvitamin D (25(OH)D) sufficiency group (25(OH)D ≧50 nmol/L) and the deficiency group (25(OH)D < 50 nmol/L).
Riding the Wave in Rhinoplasty: Changing Paradigms or Embracing Traditional Concepts.
Facial Plast Surg Clin North Am
November 2024
Department of Surgery, University of South Alabama, Mobile, AL, USA; Fedok Plastic Surgery, 113 East Fern Avenue, Foley, AL 36535, USA. Electronic address:
Riding the gene therapy wave: challenges and opportunities for rare disease patients and clinicians.
Curr Opin Pediatr
December 2024
Department of Genetics, University of Alabama at Birmingham Heersink School of Medicine.
Purpose Of Review: A growing number of gene therapies are getting FDA-approved for pediatric rare disorders to treat once incurable diseases. Opportunities for preventing lifetime illness and improving quality of life for these patients is now becoming a reality. Challenges exist in navigating the complexities of determining which patients will benefit from these new gene therapies and how to effectively deliver them as a standard of care.
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