Road work zones are becoming increasingly common due to the aging infrastructure and the need for capacity enhancement. They present significant safety risks due to narrow lanes, uneven traffic flow, lower speed, and reduced visibility. It is particularly important to understand the role of human behavioral factors in WZ crash injury severity due to difficulty navigating such areas. Furthermore, the crash injury data available is mostly imbalanced, primarily due to the lower incidence of high-cost fatal and severe injuries, and can benefit from the use of emerging analysis techniques. This research study examines a unique dataset comprising 7,855 WZ crashes in Tennessee from 2018 to 2022 as a case study to provide useful insight into the behavioral factors associated with injury severity and how they change after adjusting for the underrepresented fatal and serious injuries within the dataset. The study applies frequentist methods and a machine learning technique enhanced with the Synthetic Minority Oversampling Technique (SMOTE), addressing the data imbalance (relatively fewer fatal and serious injuries) for useful inferences and predictions. The study results indicate that aggressive driving, overspeeding, and drunk driving significantly elevate injury severity. Additionally, after balancing the minority categories of crash injury severity levels, the importance of contributing factors changes. The study offers engineers and data analysts a framework for analyzing imbalanced data, a prevalent issue in crash injury severity analysis. By exploring key behavioral factors responsible for injury severity in WZ crashes, the study provides useful insight and valuable information to traffic safety engineers, transportation agencies, and policymakers to implement enhanced safety measures in WZ design and management, ultimately aiming to mitigate injury severity and to improve overall safety for road users.
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http://dx.doi.org/10.1016/j.aap.2024.107794 | DOI Listing |
Polymers (Basel)
December 2024
Department of Neurological Surgery, The University of Washington, Seattle, WA 98109, USA.
Spinal cord trauma leads to the destruction of the highly organized cytoarchitecture that carries information along the axis of the spinal column. Currently, there are no clinically accepted strategies that can help regenerate severed axons after spinal cord injury (SCI). Hydrogels are soft biomaterials with high water content that are widely used as scaffolds to interface with the central nervous system (CNS).
View Article and Find Full Text PDFToxics
December 2024
Department of Andrology, The First Hospital of Jilin University, Jilin University, Changchun 130021, China.
Triptolide (TP) is a diterpenoid compound extracted from the traditional Chinese medicinal herb Tripterygium wilfordii. It has antitumor and anti-inflammatory effects and stimulates immunity. However, its serious side effects, especially reproductive toxicity, limit its clinical application.
View Article and Find Full Text PDFMicroorganisms
December 2024
Department for Infectious Diseases, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
In sepsis, a balanced pro-inflammatory and anti-inflammatory response results in the bacterial clearance and resolution of inflammation, promoting clinical recovery and survival. Semaphorins, a large family of secreted and membrane-bound glycoproteins, are newly recognized biomarkers and therapeutic targets in immunological and neoplastic disorders. Although semaphorins might also be a crucial part of host defense responses to infection, their role in sepsis is yet to be determined.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
Department of Hematology and Stem Cell Transplantation, South Pest Central Hospital, National Institute of Hematology and Infectious Diseases, 1097 Budapest, Hungary.
Background: Thrombotic microangiopathy (TMA) is a potentially life-threatening complication associated with carfilzomib, a proteasome inhibitor approved for treating multiple myeloma. TMA typically presents within the initial months of treatment; however, delayed onset is rare and poses significant diagnostic challenges.
Methods: We conducted a retrospective analysis of the medical records of a 47-year-old Caucasian woman diagnosed with IgA kappa myeloma who developed signs and symptoms consistent with TMA eleven months after the initiation of carfilzomib therapy and already in ongoing very good partial remission.
Pharmaceuticals (Basel)
November 2024
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
: Endothelial hyperpermeability is the hallmark of severe disease, including sepsis and acute respiratory syndrome (ARDS). The development of medical countermeasures to treat the corresponding illness is of utmost importance. Synthetic somatostatin analogs (SSA) are FDA-approved drugs prescribed in patients with neuroendocrine tumors, and they act via growth hormone (GH) suppression.
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