AI Article Synopsis

  • Localized cystic disease of the kidney (LCDK) is a rare, non-progressive condition that can be mistaken for cancer, potentially leading to unnecessary surgeries.
  • In a study of 14 patients (ages 3-79, mostly middle-aged), most cases presented as unilateral and many patients experienced flank pain or had incidental findings.
  • The lesions were multilocular and benign, lacking malignant features, and a review of 75 other cases supports the idea that LCDK should be included in the differential diagnosis for cystic kidney lesions.

Article Abstract

Localized cystic disease of the kidney (LCDK) is rare without hereditary background and does not progress. It can mimic neoplastic process, leading to unnecessary surgical intervention. We present 14 patients [male-to-female 9:5; mean age 50.3 years (range: 3-79)] with LCDK in a multinational cohort. Flank pain (n=5) and incidental lesions (n=4) were common. All cases were unilateral (9 right, 5 left), and contralateral kidneys were mostly normal (n=11). No family history was present, and none had extrarenal solid organ cysts. Radical and partial nephrectomies were performed in 9 and 5 cases, respectively. All lesions were multilocular, ranging from 1.8 - 20cm. 2 cases had diffuse renal involvement. Cystic septa contained nonneoplastic elements including renal tubules and glomeruli without primitive epithelial cellular elements, blastema, or immature stromal cells. In addition, we also comprehensively reviewed 75 previously reported cases. Conclusions. LCDK should be considered in the differential of cystic kidney lesions.

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Source
http://dx.doi.org/10.1007/s00428-024-03930-5DOI Listing

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