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Deceased Donor Renal Allograft Utility in Adult Single and Multi-organ Transplantation in the United States.
Transplant Direct
January 2025
Department of Surgery, Division of Transplantation, Thomas Jefferson University Hospital, Philadelphia, PA.
Background: Deceased donor multiorgan transplants utilizing kidneys (MOTs) can improve outcomes for multiorgan recipients but reduces kidneys for chronic renal failure patients.
Methods: We reviewed the Organ Procurement and Transplantation Network database from 2015 through 2019, for adult deceased donor kidney transplants. Recipients were classified as kidney transplant alone (KTA) (n = 62,252) or MOTs pancreas-kidney, simultaneous pancreas-kidney (n = 3,976), liver-kidney, simultaneous liver-kidney (n = 3,212), heart-kidney, simultaneous heart-kidney (n = 808), and "other"-kidney, simultaneous "other" kidney (n = 73).
Nidogen 2 Overexpression Promotes Hepatosteatosis and Atherosclerosis.
Int J Mol Sci
November 2024
Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Clinical and genetic studies strongly support a significant connection between nonalcoholic fatty liver disease (NAFLD) and atherosclerotic cardiovascular disease (ASCVD) and identify ASCVD as the primary cause of death in NAFLD patients. Understanding the molecular factors and mechanisms regulating these diseases is critical for developing novel therapies that target them simultaneously. Our preliminary immunoblotting experiments demonstrated elevated expression of nidogen 2 (NID2), a basement membrane glycoprotein, in human atherosclerotic vascular tissues and murine steatotic livers.
View Article and Find Full Text PDFCompound Tongyang Fumai decoction improves quality of life in sick sinus syndrome: a randomized controlled study.
J Tradit Chin Med
December 2024
Cardiovascular Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Objective: To evaluate the efficacy of Tongyang Fumai decoction (, TYFM) on the quality of life (QOL) as a complementary therapy for sick sinus syndrome (SSS).
Methods: This randomized controlled study involved 224 patients with symptomatic SSS. Patients were randomly assigned to either the TYFM group or the control group (receiving theophylline sustained-release tablets).
Evolving indications and management patterns in heart - kidney transplantation.
Curr Opin Nephrol Hypertens
January 2025
Division of Cardiology, Department of Medicine, University of Wisconsin - Madison, Madison, Wisconsin, USA.
Article Synopsis
- Dual heart-kidney transplantation (HKT) is an emerging treatment for patients with severe heart failure and kidney issues, with new guidelines from UNOS in 2023 formalizing its indications.
- Recent studies indicate that simultaneous heart-kidney transplantation (SHKT) offers better outcomes than heart transplantation alone for certain patients with renal problems, while kidney-after-heart transplantation (KAHT) serves as a safety option.
- Advances in pre- and post-transplant management, including device trials and innovative drug regimens, alongside future research in AI and biomarkers, highlight the potential of dual HKT as a vital option for patients with limited alternatives.
New insights into the intestinal barrier through "gut-organ" axes and a glimpse of the microgravity's effects on intestinal barrier.
Front Physiol
October 2024
Department of General Surgery, The Ninth Medical Center of PLA General Hospital, Beijing, China.
Gut serves as the largest interface between humans and the environment, playing a crucial role in nutrient absorption and protection against harmful substances. The intestinal barrier acts as the initial defense mechanism against non-specific infections, with its integrity directly impacting the homeostasis and health of the human body. The primary factor attributed to the impairment of the intestinal barrier in previous studies has always centered on the gastrointestinal tract itself.
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