AI Article Synopsis
- Langerhans cell sarcoma (LCS) is a rare and aggressive type of cancer that arises from Langerhans cells and is characterized by high levels of mitotic activity and atypical cell forms.
- While LCS primarily affects adults, there have been a few documented cases in children, which show diverse clinical results.
- The text discusses two specific childhood cases of LCS that displayed high-grade sarcomatous characteristics and were found to have a fusion and BRAF V600E mutation.
Article Abstract
Langerhans cell sarcoma (LCS), a rare malignant neoplasm in the general category of myeloid neoplasms characterized by overtly malignant Langerhans cells (LC) with conspicuous mitotic activity including atypical forms. Although most cases occur in adults, rare examples of LCS have been reported in children with variable clinical outcome. We present 2 childhood cases of Langerhans cell neoplasm with high grade sarcomatous features and fusion and BRAF V600E mutation.
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| http://dx.doi.org/10.1177/10935266241281517 | DOI Listing |
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