AI Article Synopsis
- This study evaluated the safety and immune response of various COVID-19 vaccines among healthcare workers in Taiwan during the Omicron variant outbreak, comparing their effectiveness.
- Conducted from March 2021 to July 2023, the research involved 710 healthcare workers who received different vaccines, with blood samples taken to measure antibody levels and record side effects.
- Results showed that mRNA vaccines like Moderna offered the highest initial antibody levels and effectiveness, while regular booster doses significantly boosted immunity and reduced COVID-19 cases among workers.
Article Abstract
Background/objectives: This study aimed to assess the reactogenicity and immunogenicity of various SARS-CoV-2 vaccines and compare their protective effects against COVID-19 among healthcare workers (HCWs) during the Omicron outbreak in Taiwan.
Methods: Conducted from March 2021 to July 2023, this prospective observational study included healthy HCWs without prior COVID-19 immunization. Participants chose between adenovirus-vectored (AstraZeneca), mRNA (Moderna, BioNTech-Pfizer), and protein-based (Medigen, Novavax) vaccines. Blood samples were taken at multiple points to measure neutralizing antibody (nAb) titers, and adverse events (AEs) were recorded via questionnaires.
Results: Of 710 HCWs, 668 (94.1%) completed three doses, and 290 (40.8%) received a fourth dose during the Omicron outbreak. AEs were more common with AstraZeneca and Moderna vaccines, while Medigen caused fewer AEs. Initial nAb titers were highest with Moderna but waned over time regardless of the vaccine. Booster doses significantly increased nAb titers, with the highest levels observed in Moderna BA1 recipients. The fourth dose significantly reduced COVID-19 incidence, with Moderna BA1 being the most effective.
Conclusions: Regular booster doses, especially with mRNA and adjuvant-protein vaccines, effectively enhance nAb levels and reduce infection rates, providing critical protection for frontline HCWs during variant outbreaks.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435596 | PMC |
| http://dx.doi.org/10.3390/vaccines12091057 | DOI Listing |
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