AI Article Synopsis
- dNTPs are super important for making sure DNA gets copied and stays healthy in cells.
- Different enzymes like DHFR, RNR, and SAMHD1 help manage the amounts of dNTPs in the cell to make sure everything runs smoothly.
- The balance of dNTPs can even affect how viruses interact with our cells and the genes that help break down these building blocks.
Article Abstract
Deoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of genomic information within cells. The balance of the dNTP pool involves several cellular enzymes, including dihydrofolate reductase (DHFR), ribonucleotide reductase (RNR), and SAM and HD domain-containing protein 1 (SAMHD1), among others. DHFR is vital for the de novo synthesis of purines and deoxythymidine monophosphate, which are necessary for DNA synthesis. SAMHD1, a ubiquitously expressed deoxynucleotide triphosphohydrolase, converts dNTPs into deoxynucleosides and inorganic triphosphates. This process counteracts the de novo dNTP synthesis primarily carried out by RNR and cellular deoxynucleoside kinases, which are most active during the S phase of the cell cycle. The intracellular levels of dNTPs can influence various viral infections. This review provides a concise summary of the interactions between different viruses and the genes involved in dNTP metabolism.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437409 | PMC |
| http://dx.doi.org/10.3390/v16091412 | DOI Listing |
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