Sensitivity of normal gray and mutant beige (pink-eyed dilution mutation) Djungarian hamsters to the carcinogenic activity of 7,12-dimethylbenz (a) anthracene (DMBA) and 3-methylcholanthrene (MC) was studied. No differences between these two groups of animals which were given pills with DMBA were revealed. At the same time the beige females were found to be more sensitive to MC than males and hamsters of wild (gray) colour. Among tumours induced both by DMBA and MC fibrosarcomas prevailed both in the gray and beige hamsters. Fibrous histiocytomas were detected only in the MC-infected hamsters. Epithelial tumours were found only in females.
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Horm Behav
January 2025
Department of Psychology, University at Buffalo, SUNY, Buffalo, NY, USA; Neuroscience Program, University at Buffalo, SUNY, Buffalo, NY, USA; Evolution, Ecology, and Behavior Program, University at Buffalo, SUNY, NY, USA.
Anxiety is among the most prevalent mental health issues in children. While it is well established that gonadal steroids influence anxiety-like behavior in adulthood, a potential role in prepubertal juveniles has been overlooked because it is commonly thought that the gonads are quiescent during the juvenile period. However, the juvenile gonads secrete measurable amounts of steroids, and we have recently found that prepubertal ovariectomy decreases anxiety-like behavior of juvenile Siberian hamsters in the light/dark box test.
View Article and Find Full Text PDFChemosphere
February 2025
Centre National de La Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 8 Allée Du Général Rouvillois, 67000, Strasbourg, France. Electronic address:
In nature, species synchronize reproduction and energy metabolism with seasons to optimize survival and growth. This study investigates the effect of oral exposure to bisphenol A (BPA) on phenotypic and neuroendocrine seasonal adaptations in the Djungarian hamster, which in contrast to conventional laboratory rodents, is a well-recognized seasonal model. Adult female and male hamsters were orally exposed to BPA (5, 50, or 500 μg/kg/d) or vehicle during a 10-week transition from a long (LP) to short (SP) photoperiod (winter transition) or vice versa (summer transition).
View Article and Find Full Text PDFGenetics
November 2024
Department of Biological Sciences, University of Denver, Denver, CO 80208, USA.
Hybrid incompatibilities are a critical component of species barriers and may arise due to negative interactions between divergent regulatory elements in parental species. We used a comparative approach to identify common themes in the regulatory phenotypes associated with hybrid male sterility in two divergent rodent crosses, dwarf hamsters and house mice. We investigated three potential characteristic gene expression phenotypes in hybrids including the propensity of transgressive differentially expressed genes towards over or underexpression, the influence of developmental stage on patterns of misexpression, and the role of the sex chromosomes on misexpression phenotypes.
View Article and Find Full Text PDFPLoS One
October 2024
Institute of Neurobiology, Ulm University, Ulm, Germany.
Although the Djungarian hamster (Phodopus sungorus) is a seasonality model, it presents substantial variability in winter acclimation. In response to short photoperiod, some individuals express a suite of winter traits such as low body mass, regressed gonads, white fur, and daily torpor, while others develop only some adjustments or maintain a summer phenotype. Despite comprehensive research, the mechanisms underlying polymorphism of winter phenotype are still unknown.
View Article and Find Full Text PDFEBioMedicine
October 2024
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, Berlin, Germany. Electronic address:
Background: Translating findings from animal models to human disease is essential for dissecting disease mechanisms, developing and testing precise therapeutic strategies. The coronavirus disease 2019 (COVID-19) pandemic has highlighted this need, particularly for models showing disease severity-dependent immune responses.
Methods: Single-cell transcriptomics (scRNAseq) is well poised to reveal similarities and differences between species at the molecular and cellular level with unprecedented resolution.
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