AI Article Synopsis
- Increased focus on intranasal delivery systems for both local and systemic treatment, including CNS disorders and vaccines.
- The nasal cavity's unique anatomy is beneficial for delivering active pharmaceutical ingredients (APIs), but challenges in the delivery process exist.
- Various micro- and nanosystems, like liposomal systems and polymer particles, are being researched to enhance the effectiveness of nasal preparations for different diseases.
Article Abstract
In recent decades, there has been an increased interest in the development of intranasal delivery systems for active pharmaceutical ingredients (APIs) not only for treating local nasal diseases but also for treating systemic diseases, central nervous system (CNS) disorders, and vaccine delivery. The nasal cavity possesses a unique set of anatomical characteristics for delivering active pharmaceutical ingredients, but there are several limitations that recent research in the field of the intranasal administration of APIs aims to overcome. For the effective delivery of nasal preparations, active pharmaceutical ingredients are incorporated into various micro- and nanosystems. Some of the most commonly encountered API delivery systems in the scientific literature include liposomal systems, polymer particles with mucoadhesive properties, in situ gels, nano- and microemulsions, and solid lipid particles. This article provides a review of research on the development of nasal preparations for treating local nasal cavity diseases (in particular, for antibiotic delivery), systemic diseases (analgesics, drugs for cardiovascular diseases, antiviral and antiemetic drugs), CNS disorders (Alzheimer's disease, Parkinson's disease, epilepsy, schizophrenia, depression), and vaccine delivery. The literature data show that active research is underway to reformulate drugs of various pharmacotherapeutic groups into a nasal form.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435088 | PMC |
| http://dx.doi.org/10.3390/ph17091180 | DOI Listing |
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