AI Article Synopsis
- * A new treatment approach combining fractional carbon dioxide laser (FCL) with topical tacrolimus showed positive results in three AA cases resistant to corticosteroids for over a year.
- * After 16 weeks of combined treatment, all patients demonstrated improvement, indicating FCL and tacrolimus might be a promising therapy, but more research is necessary to confirm these findings.
Article Abstract
Alopecia areata (AA) is a non-scarring autoimmune disease requiring long-term treatments. Topical, intralesional or systemic corticosteroids are the first option. However, considering the risk of skin atrophy and the possible lack of clinical response, new treatment options are urgently needed. A fractional carbon dioxide laser (FCL) has been proven to be effective alone or in combination with other drugs. However, no study has ever evaluated the association between FCL and topical tacrolimus. We report three cases of AA resistant to corticosteroids for at least 12 months, treated with topical tacrolimus 0.1% ointment and FCL on some patches. After 16 weeks from the beginning of treatment, all patients showed improvement in clinical and trichoscopic parameters in the areas treated in combination. FCL and tacrolimus may represent a new therapeutic option, but further studies are needed for confirmation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11433324 | PMC |
| http://dx.doi.org/10.3390/life14091128 | DOI Listing |
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