AI Article Synopsis
- A complement imbalance in lung alveolar tissue can worsen COVID-19, potentially leading to acute respiratory distress syndrome (ARDS), with CD55 playing a key role in regulating this process.
- The study compared lung tissues from COVID-19 patients with and without ARDS, focusing on the expression of CD55 and the structural integrity of the alveolar walls.
- Findings revealed that lungs from patients without ARDS had better structural organization and higher CD55 expression, suggesting that enhancing CD55 levels could be a potential therapeutic approach for COVID-19-related lung damage.
Article Abstract
Background: A complement imbalance in lung alveolar tissue can play a deteriorating role in COVID-19, leading to acute respiratory distress syndrome (ARDS). CD55 is a transmembrane glycoprotein that inhibits the activation of the complement system at the intermediate cascade level, blocking the activity of the C3 convertase.
Objective: In our study, lung specimens from COVID-19 and ARDS-positive COVID+/ARDS+ patients were compared with COVID-19 and ARDS-negative COVID-/ARDS- as well as COVID-/ARDS+ patients.
Methods: Histochemical staining and immunolabeling of CD55 protein were performed.
Results: The COVID-/ARDS- specimen showed higher expression and homogeneous distribution of glycosaminoglycans as well as compactly arranged elastic and collagen fibers of the alveolar walls in comparison to ARDS-affected lungs. In addition, COVID-/ARDS- lung tissues revealed stronger and homogenously distributed CD55 expression on the alveolar walls in comparison to the disrupted COVID-/ARDS+ lung tissues.
Conclusions: Even though the collapse of the alveolar linings and the accumulation of cellular components in the alveolar spaces were characteristic of COVID+/ARDS+ lung tissues, evaluating CD55 expression could be relevant to understand its relation to the disease. Furthermore, targeting CD55 upregulation as a potential therapy could be an option for post-infectious complications of COVID-19 and other inflammatory lung diseases in the future.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11432792 | PMC |
| http://dx.doi.org/10.3390/life14091058 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!