: Repetitive transcranial magnetic stimulation (rTMS) has recently demonstrated significant potential in treating obsessive-compulsive disorder (OCD). However, its effectiveness depends on various parameters, including stimulation parameters, OCD subtypes and electrical fields (EFs) induced by rTMS in targeted brain regions that are less studied. : Using the PRISMA approach, we examined 27 randomized control trials (RCTs) conducted from 1985 to 2024 using rTMS for the treatment of OCD and conducted several meta-analyses to investigate the role of rTMS parameters, including the EFs induced by each rTMS protocol, and OCD subtypes on treatment efficacy. : A significant, medium effect size was found, favoring active rTMS (g = 0.59, < 0.0001), which was larger for the obsession subscale. Both supplementary motor area (SMA) rTMS (g = 0.82, = 0.048) and bilateral dorsolateral prefrontal cortex (DLPFC) rTMS (gPPC = 1.14, = 0.04) demonstrated large effect sizes, while the right DLPFC showed a significant moderate effect size for reducing OCD severity (g = 0.63, = 0.012). These protocols induced the largest EFs in dorsal cognitive, ventral cognitive and sensorimotor circuits. rTMS protocols targeting DLPFC produced the strongest electrical fields in cognitive circuits, while pre-supplementary motor area (pre-SMA) and orbitofrontal cortex (OFC) rTMS protocols induced larger fields in regions linked to emotional and affective processing in addition to cognitive circuits. The pre-SMA rTMS modulated more circuits involved in OCD pathophysiology-sensorimotor, cognitive, affective, and frontolimbic-with larger electrical fields than the other protocols. : While rTMS shows moderate overall clinical efficacy, protocols targeting ventral and dorsal cognitive and sensorimotor circuits demonstrate the highest potential. The pre-SMA rTMS appears to induce electrical fields in more circuits relevant to OCD pathophysiology.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11432318 | PMC |
| http://dx.doi.org/10.3390/jcm13185358 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recent achievements in noble metal-based oxide electrocatalysts for water splitting.
Mater Horiz
January 2025
Qilu Lake Field Scientific Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Institute for Ecological Research and Pollution Control of Plateau Lakes, School of Ecology and Environmental Science, Yunnan University, Kunming 650504, China.
The search for sustainable energy sources has accelerated the exploration of water decomposition as a clean H production method. Among the methods proposed, H production water electrolysis has garnered considerable attention. However, the process of H production from water electrolysis is severely limited by the slow kinetics of the anodic oxygen evolution reaction and large intrinsic overpotentials at the anode; therefore, suitable catalysts need to be found to accelerate the reaction rate.
View Article and Find Full Text PDFContinuous Polarizability-Based Separation of Lithium Iron Phosphate and Graphite Using a Dielectrophoretic Particle Separator.
Langmuir
January 2025
College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China.
The recovery of valuable materials from spent lithium-ion batteries (LIBs) has experienced increasing demand in recent years. Current recycling technologies are typically energy-intensive and are often plagued by high operation costs, low processing efficiency, and environmental pollution concerns. In this study, an efficient and environmentally friendly dielectrophoresis (DEP)-based approach is proposed to separate the main components of "black mass" mixtures from LIBs, specifically lithium iron phosphate (LFP) and graphite, based on their polarizability differences.
View Article and Find Full Text PDFInsulator-donor electron wavefunction coupling in pseudo-bilayer organic solar cells achieving a certificated efficiency of 19.18.
Natl Sci Rev
January 2025
School of Physics, State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China.
The incorporation of polymeric insulators has led to notable achievements in the field of organic semiconductors. By altering the blending concentration, polymeric insulators exhibit extensive capabilities in regulating molecular configuration, film crystallinity, and mitigation of defect states. However, current research suggests that the improvement in such physical properties is primarily attributed to the enhancement of thin film morphology, an outcome that seems to be an inevitable consequence of incorporating insulators.
View Article and Find Full Text PDFUnlocking new possibilities in ionic thermoelectric materials: a machine learning perspective.
Natl Sci Rev
January 2025
Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China.
The high thermopower of ionic thermoelectric (-TE) materials holds promise for miniaturized waste-heat recovery devices and thermal sensors. However, progress is hampered by laborious trial-and-error experimentations, which lack theoretical underpinning. Herein, by introducing the simplified molecular-input line-entry system, we have addressed the challenge posed by the inconsistency of -TE material types, and present a machine learning model that evaluates the Seebeck coefficient with an of 0.
View Article and Find Full Text PDFPurpose: To theoretically and experimentally study implant lead tip heating caused by radiofrequency (RF) power deposition in different wire configurations that contain loop(s).
Methods: Maximum temperature rise caused by RF heating was measured at 1.5T on 20 insulated, capped wires with various loop and straight segment configurations.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!