AI Article Synopsis
- Food allergy (FA) affects around 6-8% of young children, with tree nut and peanut allergies being major causes of severe allergic reactions (anaphylaxis).
- The oral food challenge (OFC) is the most reliable method for diagnosing food allergies, while skin prick tests (SPTs) and serum specific IgE (sIgE) tests are also commonly used.
- Evidence on the predictive value of SPTs and sIgE regarding OFC outcomes is inconsistent, indicating that while these tests can sometimes provide insights, OFC is still the definitive diagnosis method for food allergies.
Article Abstract
Food allergy (FA) affects approximately 6-8% of young children, with a peak prevalence at approximately one year of age. Tree nut and peanut allergies are among the main causes of anaphylaxis in the world. The gold standard for the diagnosis of FAs is the oral food challenge (OFC). Other diagnostic tests used in the clinical practice are skin prick tests (SPTs) and laboratory tests to measure out the presence of serum specific IgE (sIgE). In this narrative review, we collect the current evidence of the predictive value (PV) of SPTs and sIgE for the outcome of the OFCs. In literature, data are conflicting as to whether increasing sIgE concentration and wheal size in SPTs correlate with OFC outcomes. Most studies included in our review have shown that in vivo and in vitro tests may predict OFC outcomes with variable PV, but data are not conclusive; therefore, the OFC currently remains the gold standard for FA diagnosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11431423 | PMC |
| http://dx.doi.org/10.3390/diagnostics14182069 | DOI Listing |
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