Hydrogen Sulfide: A Versatile Molecule and Therapeutic Target in Health and Diseases.

Biomolecules

Department of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.

Published: September 2024

In recent years, research has unveiled the significant role of hydrogen sulfide (HS) in many physiological and pathological processes. The role of endogenous HS, HS donors, and inhibitors has been the subject of studies that have aimed to investigate this intriguing molecule. The mechanisms by which HS contributes to different diseases, including inflammatory conditions, cardiovascular disease, viral infections, and neurological disorders, are complex. Despite noteworthy progress, several questions remain unanswered. HS donors and inhibitors have shown significant therapeutic potential for various diseases. This review summarizes our current understanding of HS-based therapeutics in inflammatory conditions, cardiovascular diseases, viral infections, and neurological disorders.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11430449PMC
http://dx.doi.org/10.3390/biom14091145DOI Listing

Publication Analysis

Top Keywords

hydrogen sulfide
8
donors inhibitors
8
inflammatory conditions
8
conditions cardiovascular
8
viral infections
8
infections neurological
8
neurological disorders
8
sulfide versatile
4
versatile molecule
4
molecule therapeutic
4

Similar Publications

Photocatalytic Methanol Dehydrogenation with Switchable Selectivity.

J Am Chem Soc

January 2025

Department of Chemistry, University of California, Berkeley, California 94720, United States.

Switchable selectivity achieved by altering reaction conditions within the same photocatalytic system offers great advantages for sustainable chemical transformations and renewable energy conversion. In this study, we investigate an efficient photocatalytic methanol dehydrogenation with controlled selectivity by varying the concentration of nickel cocatalyst, using zinc indium sulfide nanocrystals as a semiconductor photocatalyst, which enables the production of either formaldehyde or ethylene glycol with high selectivity. Control experiments revealed that formaldehyde is initially generated and can either serve as a terminal product or intermediate in producing ethylene glycol, depending on the nickel concentration in the solution.

View Article and Find Full Text PDF

Sequential Infiltration Synthesis of Cadmium Sulfide Discrete Atom Clusters.

Angew Chem Int Ed Engl

January 2025

Material Science Division, Argonne National Laboratory, 9700 South Cass Avenue, Lemont, Illinois, 60439, United States.

Exposure of soft material templates to alternating volatile chemical precursors can produce inorganic deposition within the permeable template (e.g. a polymer thin film) in a process akin to atomic layer deposition (ALD).

View Article and Find Full Text PDF

Efficient separation of hydrogen isotopes, especially deuterium (D2), is pivotal for advancing industries such as nuclear fusion, semiconductor processing, and metabolic imaging. Current technologies, including cryogenic distillation and Girdler sulfide processes, suffer from significant limitations in selectivity and cost-effectiveness. Herein, we introduce a novel approach utilizing an imidazolium-based Metal-Organic Framework (MOF), JCM-1, designed to enhance D2/H2 separation through temperature-dependent gate-opening controlled by ion exchange.

View Article and Find Full Text PDF

Background: Food safety has attracted increasing attention in recent years. Harmful gases often produced during food storage have devastating effects on human health and ecosystems, and identifying and detecting them is essential. To date, many traditional methods have been used to monitor the freshness of food products.

View Article and Find Full Text PDF

Lysosome-targeted dual-locked NIR fluorescent probe for visualization of HS and viscosity in drug-induced liver injury and tumor models.

Anal Chim Acta

February 2025

Department of Radiology, Changhai Hospital, Naval Medical University, Changhai Road 168, Shanghai 200433, China. Electronic address:

Background: Lysosomes, as an indispensable subcellular organelle have numerous physiological functions closely associated with HS and viscosity, and accurate assessment of HS/viscosity fluctuations in lysosomes is essential for gaining a comprehensive understanding of lysosome-related physiological activities and pathological processes. The previous single-response fluorescent probes for either HS or viscosity alone have the potential to generate "false positive" signals in a complex biological environment. In contrast, dual-locked probes can simultaneously respond to multiple targets simultaneously, which could effectively eliminate this defect.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!