AI Article Synopsis
- * The review identifies various chemokines that contribute to obesity by triggering inflammation and affecting metabolism, highlighting the importance of immune cell recruitment.
- * Exercise has been shown to positively influence chemokine levels in obese individuals, suggesting that aerobic and resistance training could be effective strategies for improving metabolic health and reducing inflammation related to obesity.
Article Abstract
Obesity is a global health crisis that is closely interrelated to many chronic diseases, such as cardiovascular disease and diabetes. This review provides an in-depth analysis of specific chemokines involved in the development of obesity, including C-C motif chemokine ligand 2 (CCL2), CCL3, CCL5, CCL7, C-X-C motif chemokine ligand 8 (CXCL8), CXCL9, CXCL10, CXCL14, and XCL1 (lymphotactin). These chemokines exacerbate the symptoms of obesity by either promoting the inflammatory response or by influencing metabolic pathways and recruiting immune cells. Additionally, the research highlights the positive effect of exercise on modulating chemokine expression in the obese state. Notably, it explores the potential effects of both aerobic exercises and combined aerobic and resistance training in lowering levels of inflammatory mediators, reducing insulin resistance, and improving metabolic health. These findings suggest new strategies for obesity intervention through the modulation of chemokine levels by exercise, providing fresh perspectives and directions for the treatment of obesity and future research.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11430256 | PMC |
| http://dx.doi.org/10.3390/biom14091121 | DOI Listing |
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