AI Article Synopsis
- Some bladder cancers resist treatments that help the immune system fight them.
- A gene called ACSM6 makes these cancers grow and spread more, while also preventing immune cells from attacking the tumor.
- High levels of ACSM6 are linked to patients living shorter lives, so it might help doctors understand how the cancer is getting worse.
Article Abstract
Resistance to immunotherapy in bladder cancer has greatly limited its clinical application. Through single-cell sequencing, we determined that ACSM6, an oncogene that is highly expressed in bladder cancer, promotes the abilities of proliferation, cloning, migration, and invasion. The key point is that ACSM6 can also lead to a non-inflammatory immune microenvironment by inhibiting the chemotaxis and tumor killing ability of CD8 T cells. Survival analysis revealed that high ACSM6 expression was associated with shorter overall survival in the immunotherapy cohort. In summary, ACSM6 is expected to become a novel biomarker for predict bladder cancer progression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437728 | PMC |
| http://dx.doi.org/10.1186/s40364-024-00657-y | DOI Listing |
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