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Spectroscopic and in silico data indicate that phenolic acids interact with aldose reductase with different degrees of affinity at a single binding site.
Int J Biol Macromol
January 2025
INBIAS-CONICET, Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, 5800 Córdoba, Argentina. Electronic address:
Our previous studies demonstrated that the enzyme aldose reductase (AR) is activated by its interaction with tubulin, a mechanism which can lead to the emergence of secondary diseases in diabetic patients. We also found that different compounds derived from phenolic acid (CAFs) can prevent this interaction and thus AR activation. Here, we used spectroscopic and bioinformatic techniques to explore the interaction between AR and three CAFs: 3-nitrotyrosine (NTyr), Tyrosine (Tyr), and vanillic acid (Van).
View Article and Find Full Text PDFAldose reductase (ALR) is closely related to the plant's response to abiotic stresses. Previous transcriptome data from the salt-tolerant Tritipyrum Y1805 indicated that an ALR-related gene was highly upregulated under salt stress. The gene, TtALR1, was successfully cloned from Y1805, with a coding sequence length of 960 bp.
View Article and Find Full Text PDFImpaired Exercise Capacity in High-Risk Diabetic Cardiomyopathy: The ARISE-HF Cardiopulmonary Exercise Testing Subanalysis.
Circ Heart Fail
January 2025
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston (Y.L., J.L.J., G.D.L.).
Background: Objective indices of functional capacity in patients with diabetic cardiomyopathy and stage B heart failure (HF) have not been comprehensively defined. We sought to characterize the cardiopulmonary exercise characteristics of individuals with diabetic cardiomyopathy at high risk for overt HF.
Methods: The relationships from cardiopulmonary exercise testing with clinical and laboratory characteristics of participants with diabetic cardiomyopathy were evaluated using baseline data from the ARISE-HF trial (Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure).
Decoding the SARS-CoV-2 infection process: Insights into origin, spread, and therapeutic approaches.
Microb Pathog
January 2025
Department of Bioengineering, Faculty of Engineering, Integral University, Lucknow, 226026, India. Electronic address:
Article Synopsis
- Over 768 million confirmed COVID-19 cases and 6.9 million deaths have been recorded globally by July 17, 2023, highlighting the devastating impact of the pandemic.
- SARS-CoV-2, the virus responsible for COVID-19, has a complex structure, including a large RNA genome and an envelope that aids in its infectivity, although its exact origin remains unclear.
- The review discusses various topics related to COVID-19, including its origins, implications for health and the economy, and a controversial link between SARS-CoV-2 and the enzyme aldose reductase, which could have implications for treatment and understanding of the virus's pathogenesis.
Adenocarpine, Marmesin, and Lycocernuine from Ficus benjamina as Promising Inhibitors of Aldose Reductase in Diabetes: A Bioinformatics-Guided Approach.
Appl Biochem Biotechnol
January 2025
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Diabetes affects approximately 422 million people worldwide, leading to 1.5 million deaths annually and causing severe complications such as kidney failure, neuropathy, and cardiovascular disease. Aldose reductase (AR), a key enzyme in the polyol pathway, is an important therapeutic target for managing these complications.
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