AI Article Synopsis
- Endovascular ultrasound renal denervation (uRDN) was shown to lower blood pressure effectively over 36 months in patients with resistant hypertension in the RADIANCE-HTN TRIO trial.
- The trial involved 69 patients receiving uRDN and 67 patients receiving a sham procedure, with follow-up showing significant blood pressure reductions from baseline and screening measurements.
- Results indicated that uRDN maintained its effectiveness without major safety issues throughout the 36-month follow-up period.
Article Abstract
Endovascular ultrasound renal denervation (uRDN) reduced blood pressure (BP) compared to sham at 2 months in patients with resistant hypertension in the multicenter, blinded, randomized, sham-controlled RADIANCE-HTN TRIO trial. This analysis evaluates longer-term outcomes of patients randomized to uRDN. Patients with resistant hypertension to a 3-drug combination pill were randomized to uRDN (n = 69) or sham (n = 67). From 2-5 months, patients followed a standardized anti-hypertensive medication (AHM) titration protocol. At 6 months, patients were unblinded and received AHM per standard of care. In the uRDN group, 71% (49/69) completed 36-month follow-up. Screening office BP was 159/103 on 3.9 AHM. Baseline office BP on the single-pill combination was 153/99 mmHg. At 36 months, office BP changed by -14.5 ± 26.1/-9.0 ± 14.8 mmHg from screening (p < 0.001 for both) and -8.0 ± 24.5/-5.0 ± 14.6 mmHg from baseline (p = 0.007; p = 0.022) on 3.7 AHM. The efficacy of uRDN was durable to 36 months in patients with resistant hypertension with no safety concerns.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618087 | PMC |
| http://dx.doi.org/10.1038/s41440-024-01854-w | DOI Listing |
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