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http://dx.doi.org/10.1007/s12035-024-04523-8 | DOI Listing |
Mol Neurobiol
November 2024
Research Center of Neuroscience, Jiaxing University, Jiaxing, China.
Mol Neurobiol
September 2024
Research Center of Neuroscience, Jiaxing University, Jiaxing, China.
Vet Microbiol
November 2024
Department of Endocrinology, Shenzhen Longhua District Central Hospital, Shenzhen 518110, China; School of Life Science and Engineering, Foshan University, Guangdong 528225, China. Electronic address:
The thioredoxin (Trx) system plays a vital role in protecting against oxidative stress and ensures correct disulfide bonding to maintain protein function. Our previous research demonstrated that TrxA of Streptococcus suis Serotype 2 (SS2), a clinical strain from the lung of a diseased pig, contributes to virulence but is not involved in antioxidative stress. In this study, we identified another gene in the Trx family, TrxC, which encodes a protein of 104 amino acids with a CGDC active motif and 22.
View Article and Find Full Text PDFPLoS One
April 2024
Institute of Biophysics and Physical Biochemistry and Centre of Magnetic Resonance in Chemistry and Biomedicine, University of Regensburg, Regensburg, Germany.
We present here the solution structures of the protein thioredoxin-1 from Plasmodium falciparum (PfTrx-1), in its reduced and oxidized forms. They were determined by high-resolution NMR spectroscopy at 293 K on uniformly 13C-, 15N-enriched, matched samples allowing to identification of even small structural differences. PfTrx-1 shows an α/β-fold with a mixed five-stranded β-sheet that is sandwiched between 4 helices in a β1 α1 β2 α2 β3 α3 β4 β5 α4 topology.
View Article and Find Full Text PDFMol Cell Biochem
May 2024
Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, No.277 Yanta West Road, Yanta District, Xi'an, 710061, Shaanxi, China.
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