AI Article Synopsis
- This study looked at how a protein called Galectin-9 (Gal-9) relates to the health of patients with a serious liver problem called acute-on-chronic liver failure.
- Researchers found that Gal-9 levels were much higher in patients with this liver problem compared to those with just chronic hepatitis B.
- The results suggested that higher levels of Gal-9 might mean a better chance of survival, as it helped predict how well patients would do over time.
Article Abstract
Galectin-9 (Gal-9) expression in patients with acute-on-chronic liver failure and its correlation with prognosis remain unclear. This study investigated the relationship between liver failure prognosis and Gal-9 expression analysis in patients with acute-on-chronic liver failure. Patients with acute-on-chronic liver failure attributable to hepatitis B and those with chronic hepatitis B were included in this single-center prospective cohort study. The Gal-9 levels in the acute-on-chronic liver failure group were significantly higher than those in the chronic hepatitis B group, and there was an upregulation of Gal-9 and T-cell immunoglobulin domain and mucin domain-3 expressions in peripheral blood T cells. Gal-9 was localized in the regenerative areas of liver tissues in patients with acute-on-chronic liver failure, co-localizing with Kupffer cells. Kaplan-Meier survival curves showed that patients with Gal-9 levels < 9.6 ng/ml had a worse prognosis, with the area under the receiver operating characteristic curve (AUC-ROC) being similar to that of the Model for End-Stage Liver Disease score. The combined ROC curve of the two had better predictive performance, with an AUC of 0.945. High Gal-9 levels in liver regenerative areas can serve as a prognostic marker, indicating a better prognosis for patients with hepatitis B virus-acute-on-chronic liver failure.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437140 | PMC |
| http://dx.doi.org/10.1038/s41598-024-73397-6 | DOI Listing |
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