Physiologic changes of pregnancy and considerations for screening and diagnosis of sepsis.

Semin Perinatol

NewYork-Presbyterian, New York, NY, USA; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Center for Patient Safety Science, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address:

Published: November 2024

AI Article Synopsis

  • Obstetric sepsis is a major health risk for pregnant individuals globally, leading to serious complications and increased mortality rates.
  • Early assessment and prompt treatment are essential for improving health outcomes for both mothers and their newborns affected by peripartum sepsis.
  • Understanding the unique physiological and hemodynamic changes during pregnancy is vital for effectively diagnosing and managing septic conditions in pregnant patients.

Article Abstract

Obstetric sepsis is a significant cause of morbidity and mortality in pregnant people worldwide. Initial evaluation and timely intervention are crucial to improving outcomes for birthing persons and their newborns. While many of the therapies and interventions for peripartum sepsis are consistent with the general population, there are considerations unique to pregnancy. Stabilization of the septic pregnant or immediately postpartum patient requires an understanding of the physiologic changes of pregnancy, hemodynamic changes during labor, and infections specific to pregnancy. We will review the interaction between pregnant physiology and sepsis pathophysiology, and how this can guide screening and diagnosis.

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Source
http://dx.doi.org/10.1016/j.semperi.2024.151973DOI Listing

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