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Self-Assembly of Human Fibrinogen into Microclot-Mimicking Antifibrinolytic Amyloid Fibrinogen Particles.
ACS Appl Bio Mater
December 2024
MOE Key Laboratory of Bio-Intelligent Manufacturing, Liaoning Key Laboratory of Molecular Recognition and Imaging, School of Bioengineering, Dalian University of Technology, Dalian 116024, China.
Recent clinical studies have highlighted the presence of microclots in the form of amyloid fibrinogen particles (AFPs) in plasma samples from Long COVID patients. However, the clinical significance of these abnormal, nonfibrillar self-assembly aggregates of human fibrinogen remains debated due to the limited understanding of their structural and biological characteristics. In this study, we present a method for generating mimetic microclots in vitro.
View Article and Find Full Text PDF[Deep vein thrombosis of the lower limb : from diagnosis to treatment].
Rev Med Suisse
December 2024
Service d'angiologie et d'hémostase, Hôpitaux universitaires de Genève, 1211 Genève 14.
When a deep vein thrombosis (DVT) is suspected, management should begin with a well-defined diagnostic approach based on clinical evaluation and pre-test probability, D-dimer testing, and venous ultrasound. Once the diagnosis is confirmed, it is important to differentiate between proximal and distal DVT, as their treatment strategies differs. While numerous robust studies with a high level of evidence are available for proximal DVT, the optimal management of distal DVT remains debated.
View Article and Find Full Text PDFThe role of tranexamic acid for infection prevention after fracture fixation.
Injury
November 2024
Rashid Hospital, Trauma Department, Dubai, UAE.
Article Synopsis
- Fracture-related infections remain a global concern after surgeries, despite existing prevention measures.
- Tranexamic acid has been suggested as a protective drug that could reduce the risks of surgical wound complications and postoperative infections in orthopedic surgeries.
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Gastrointestinal bleeding among oral anticoagulant users: a comprehensive 7-year retrospective review using Türkiye's national health data system.
Turk J Med Sci
October 2024
Republic of Türkiye Ministry of Health, Ankara, Turkiye.
Background/aim: The comparative risk of gastrointestinal bleeding (GIB) among users of direct-acting oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) is a topic of ongoing debate. This study leverages a comprehensive national health database to evaluate the incidence of GIB, associated risk factors, and postbleeding management strategies among anticoagulated patients.
Materials And Methods: Utilizing the Turkish Ministry of Health's e-Nabız system, we conducted a retrospective analysis of patients treated with DOACs and warfarin from January 2017 to July 2023.
The debate on antifibrinolytics in liver transplantation: always, never, or sometimes?
Braz J Anesthesiol
September 2024
Santa Casa de Porto Alegre, Serviço de Anestesia, Porto Alegre, RS, Brazil; Faculdade de Medicina da Universidade de São Paulo (FMUSP), Programa de Pós-graduação em Anestesiologia, Ciências Cirúrgicas e Medicina Perioperatória, São Paulo, SP, Brazil; Hospital de Clínicas de Porto Alegre (HCPA), Serviço de Anestesia e Medicina Perioperatória, Porto Alegre, RS, Brazil; Hospital Nossa Senhora da Conceição, Serviço de Anestesia, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-graduação em Ciências Pneumológicas, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-graduação em Ciências Cirúrgicas, Porto Alegre, RS, Brazil. Electronic address:
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