The development of materials with high lysozyme adsorption is critical for drug delivery and skin wound applications, as it enhances antibacterial properties, stability, and controlled release of therapeutic agents, thereby improving treatment efficacy and safety. Alginate-based nanofiber scaffolds, featuring high surface area and multiple adsorption sites, can efficiently absorb lysozyme and regulate its release through tunable pore channels, offering a promising approach to chronic wound management. In this study, we fabricated poly (vinyl alcohol-co-ethylene) (EVOH) nanofiber-based sodium alginate (ENSA) aerogels using a simple two-step crosslinking procedure. The resulting aerogels, with controllable porosity formed via high-pressure spraying techniques (aerogel film) and molding (aerogel sponge), were evaluated for their high-loading capacity and controllable release of lysozyme. The aerogel film exhibited a remarkable lysozyme adsorption capacity of 1965 ± 36 mg/g, while the aerogel sponge sustained lysozyme release over 14 days. Analysis of the drug-release mechanism through four kinetic models revealed two distinct processes: cation exchange and matrix diffusion. The aerogel's pore structure influenced the diffusion processes, enabling tailored drug release profiles. Additionally, the ENSA aerogels demonstrated good mechanical properties, non-cytotoxicity, and potent antibacterial activity, positioning them as promising materials for skin wound dressings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2024.135974 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Interaction of lysozyme with solid supports cryogels containing imidazole functional group.
J Chromatogr B Analyt Technol Biomed Life Sci
December 2024
Department of Chemistry, Faculty of Science, Pamukkale University, Denizli, Turkey. Electronic address:
This paper details the preparation of acrylamide-based supermacroporous cryogels and their application in removing lysozyme from aqueous solutions. N-Vinyl imidazole was copolymerized with acrylamide as a comonomer to impart pseudo-specificity to the cryogels, forming poly(AAm-VIM) cryogel. Characterization studies to assess the physical and chemical properties of the synthesized cryogels involved swelling tests, Fourier Transform Infrared Spectroscopy (FTIR), elemental analysis, Field Emission Scanning Electron Microscopy (FESEM), and Thermogravimetric Analysis (TGA-DTA).
View Article and Find Full Text PDFSynergistic effects of silica-enriched bioactive glass and tri-calcium phosphate nanocomposites on BMP2 gene expression for bone repair and regeneration applications.
Int J Pharm
December 2024
National Centre for Nanoscience and Nanotechnology, University of Madras, Chennai 600025, India. Electronic address:
Article Synopsis
Directional anchoring of polymer-lysozyme nanohybrids for adhesive capture and enhanced removal of Alicyclobacillus acidoterrestris in fruit juices.
Food Chem
February 2025
College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, Yangling 712100, Shaanxi, China. Electronic address:
The acidophilic and heat-resistant traits of Alicyclobacillus acidoterrestris (A. acidoterrestris) present a formidable challenge to fruit juices production safety. To address the limitations of conventional thermal sterilization, a novel bacterial capture device MPDEL has been developed.
View Article and Find Full Text PDFCoassembly of Charged Copolymer Amphiphiles Featuring pH-Regulated Antifouling Properties.
Langmuir
December 2024
Polymer Research Centre and Centre for Advanced Functional Materials, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal 741246, India.
Understanding the formation of highly ordered structures through self-assembly is crucial for developing various biologically relevant systems. A significant expansion in the development of self-assembly chemistry features stable coassembly formation using a mixture of two oppositely charged polymers. This study provides insightful findings on the coassembly of hydrophobic coumarin-integrated cationic () and anionic () copolymers toward the formation of vesicles in aqueous medium at pH 7.
View Article and Find Full Text PDFAmyloid-Like Protein-Modified Carbon Nitride as a Bioinspired Material for Enhanced Photocatalytic CO Reduction.
ACS Appl Mater Interfaces
November 2024
Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Xi'an Key Laboratory of Organometallic Material Chemistry, Xi'an Key Laboratory of Polymeric Soft Matter, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, P. R. China.
Modification of g-CN with metal-free biomaterials through an environmentally friendly, low-energy, facile, and rapid single-step method is desired for the preparation of photocatalysts with efficient activity and high selectivity of CO reduction but remains a great challenge. Herein, we develop a phase-transitioned protein modification strategy for photocatalysts through superfast amyloid-like protein assembly on surfaces using a one-step sequential coating method. Metal-free carbon nitride/protein heterojunction composite photocatalysts (the phase-transitioned lysozyme (PTL), phase-transitioned bovine serum albumin (PTB), and phase-transitioned ovalbumin (PTO)-coated carbon nitride@SiO (CN@SiO) and bioinspired carbon nitride hollow nanospheres (CN-HS) obtained by etching of CN@SiO) are prepared using lysozyme, bovine serum albumin, and ovalbumin.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!