AI Article Synopsis
- Biological cells have complex structures that require accurate models to understand their behavior under external electric fields (EF), which are essential for technologies like pulsed electric fields (PEF).
- The study examines various equivalent circuit models for cells with different configurations, tackling issues related to incorporating changes in the cell membrane caused by EF interactions.
- The research suggests the need for more studies to improve these models, while also reviewing their effectiveness and limitations, ultimately aiming to enhance their applications in medical and technological fields.
Article Abstract
Biological cells, characterized by complex and dynamic structures, demand precise models for comprehensive understanding, especially when subjected to external factors such as electric fields (EF) for manipulation or treatment. This interaction is integral to technologies like pulsed electric fields (PEF), inducing reversible and irreversible structural variations. Our study explores both simplified and sophisticated equivalent circuit models for biological cells under the influence of an external EF, covering diverse cell structures from single- to double-shell configurations. The paper highlights challenges in circuit modeling, specifically addressing the incorporation of reversible or irreversible pores in the membrane during external EF interactions, emphasizing the need for further research to refine technical aspects in this field. Additionally, we review a comparative analysis of the performance and applicability of the proposed circuit models, providing insights into their strengths and limitations. This contributes to a deeper insight of the complexities associated with modeling biological cells under external EF influences, paving the way for enhanced applications in medical and technological domains in future. .
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| http://dx.doi.org/10.1088/2057-1976/ad8092 | DOI Listing |
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