AI Article Synopsis
- Enterovirus D68 (EV-D68) first appeared in 1962 and caused significant respiratory illnesses and acute flaccid myelitis during outbreaks in 2014.
- A systematic review analyzed 10 studies from six countries, focusing on the seroprevalence of EV-D68 across different age groups, revealing that seroprevalence increases rapidly with age, reaching around 100% by age 20 with no decline in adulthood.
- The review highlights the need for standardized testing protocols, understanding the role of cross-reactivity with other viruses, and assessing individual exposure to EV-D68 as key areas for future research.
Article Abstract
Enterovirus D68 (EV-D68), first isolated in 1962, emerged in 2014, causing outbreaks of severe respiratory infections and acute flaccid myelitis. In this systematic review, we have compiled all available literature on age-stratified seroprevalence estimates of EV-D68. Ten studies from six countries were retained, all conducted using microneutralisation assays, despite wide variations in protocols and challenge viruses. The age profiles of seroprevalence were similar across time and regions; seroprevalence increased quickly with age, reaching roughly 100% by the age of 20 years and with no sign of decline throughout adulthood. This suggests continuous or frequent exposure of the populations to the virus, or possible cross-reactivity with other viruses. Studies with two or more cross-sectional surveys reported consistently higher seroprevalence at later timepoints, suggesting a global increase in transmission over time. This systematic review concludes that standardising serological protocols, understanding the contribution of cross-reactivity with other pathogens to the high reported seroprevalence, and quantifying individual exposure to EV-D68 over time are the main research priorities for the future.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.lanmic.2024.07.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enterovirus A71 and coxsackievirus A6 circulation in England, UK, 2006-2017: A mathematical modelling study using cross-sectional seroprevalence data.
PLoS Pathog
November 2024
MRC Center for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom.
Enterovirus A71 (EV-A71) and coxsackievirus A6 (CVA6) primarily cause hand, foot and mouth disease and have emerged to cause potential fatal neurological and systemic manifestations. However, limited surveillance data collected through passive surveillance systems hampers characterization of their epidemiological dynamics. We fit a series of catalytic models to age-stratified seroprevalence data for EV-A71 and CVA6 collected in England at three time points (2006, 2011 and 2017) to estimate the force of infection (FOI) over time and assess possible changes in transmission.
View Article and Find Full Text PDFEstimating the force of infection of four dengue serotypes from serological studies in two regions of Vietnam.
PLoS Negl Trop Dis
October 2024
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.
Dengue is endemic in Vietnam with circulation of all four serotypes (DENV1-4) all year-round. It is hard to estimate the disease's true serotype-specific transmission patterns from cases due to its high asymptomatic rate, low reporting rate and complex immunity and transmission dynamics. Seroprevalence studies have been used to great effect for understanding patterns of dengue transmission.
View Article and Find Full Text PDFGlobal age-stratified seroprevalence of enterovirus D68: a systematic literature review.
Lancet Microbe
September 2024
Medical Research Council (MRC) Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Article Synopsis
- Enterovirus D68 (EV-D68) first appeared in 1962 and caused significant respiratory illnesses and acute flaccid myelitis during outbreaks in 2014.
- A systematic review analyzed 10 studies from six countries, focusing on the seroprevalence of EV-D68 across different age groups, revealing that seroprevalence increases rapidly with age, reaching around 100% by age 20 with no decline in adulthood.
- The review highlights the need for standardized testing protocols, understanding the role of cross-reactivity with other viruses, and assessing individual exposure to EV-D68 as key areas for future research.
Toxoplasma gondii infection is associated with schizophrenia from the perspectives of seroepidemiology and serum metabolomics in Hunan Province, China.
Microb Pathog
October 2024
Department of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, 410013, Hunan, China. Electronic address:
Toxoplasma gondii (T.gondii) can influence the host's neurotransmission, central immune responses, and brain structure, potentially impacting the onset and development of various psychiatric disorders such as schizophrenia. We employed Electrochemiluminescence Immunoassay (ECLIA) to measure anti-Toxoplasma antibodies in 451 schizophrenic patients and 478 individuals from the general population in Hunan, China.
View Article and Find Full Text PDFHigh SARS-CoV-2 Exposure in Rural Southern Mozambique After Four Waves of COVID-19: Community-Based Seroepidemiological Surveys.
Influenza Other Respir Viruses
June 2024
Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Background: Mozambique was one of many African countries with limited testing capacity for SARS-CoV-2. Serosurveys, an alternative to estimate the real exposure to understand the epidemiology and transmission dynamics, have been scarce in Mozambique. Herein, we aimed to estimate the age-specific seroprevalence of SARS-CoV-2 in the general population of the Manhiça District, at four time points, for evaluating dynamics of exposure and the impact of vaccination.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!