Controlling cyanobacterial blooms is not only an engineering and technical issue but also an optimization problem in environment management. Under budget constraints, a novel simulation-based optimization model for cyanobacterial control is constructed in this study. The simulation model is used for simulating cyanobacteria growth and diffusion processes. The optimization model is utilized to determine the optimal search and treatment path. Through the interactive coupling of simulation modeling and resource allocation optimization, this research provides decision-makers with new operational guidelines for cyanobacterial control. Our test results demonstrate that the initial invasion frequency has a greater economic impact than invasion abundance. The nearby cells to the initial invasion are affected first, and then the influence radiates outward in a diffusion pattern. Using a slow search speed and a treatment frequency of every 10 days can achieve the lowest possible economic losses in most test scenarios. Moreover, we also find that the optimal search and treatment paths revolve around the initial invasion location. This study is a typical interdisciplinary research, which can assist water resource managers in making more accurate decisions regarding cyanobacteria removal paths, removal frequencies, and treatment speeds.
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http://dx.doi.org/10.1016/j.jenvman.2024.122639 | DOI Listing |
Acta Orthop Belg
December 2024
Percutaneous intra-meniscal platelet-rich plasma (PRP) is a promising tool for managing low-grade meniscal injuries in non-athletic patients. The study evaluates the clinical and radiological outcomes of PRP intra-meniscal injection in meniscal tears. Forty-eight patients were injected with 3 injections of PRP at an interval of one week with a standardised technique under sonographic guidance.
View Article and Find Full Text PDFMol Cancer Res
January 2025
Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Malignant neoplasms arise within a region of chronic inflammation caused by tissue injuries. Inflammation is a key factor involved in all aspects of tumorigenesis including initiation, proliferation, invasion, angiogenesis, and metastasis. Interleukin-1 (IL-1) plays critical functions in tumor development with influencing the tumor microenvironment and promoting cancer progression.
View Article and Find Full Text PDFFront Oncol
January 2025
Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
Background: Recent research has highlighted lactate's crucial role in epigenetic regulation, particularly by influencing histone modifications that drive the initiation and progression of hepatocellular carcinoma (HCC). While mitochondria are known to regulate tumor behavior, the interaction between lactate metabolism and mitochondrial function in cancer tissues remains underexplored. Understanding this relationship may provide deeper insights into tumor metabolic reprogramming and reveal novel therapeutic targets for HCC and other malignancies.
View Article and Find Full Text PDFFront Immunol
January 2025
School of Nursing, Zunyi Medical University, Zunyi, China.
Background: Most patients initially diagnosed with non-muscle invasive bladder cancer (NMIBC) still have frequent recurrence after urethral bladder tumor electrodesiccation supplemented with intravesical instillation therapy, and their risk of recurrence is difficult to predict. Risk prediction models used to predict postoperative recurrence in patients with NMIBC have limitations, such as a limited number of included cases and a lack of validation. Therefore, there is an urgent need to develop new models to compensate for the shortcomings and potentially provide evidence for predicting postoperative recurrence in NMIBC patients.
View Article and Find Full Text PDFJ Allergy Clin Immunol Glob
February 2025
Department of Molecular Medicine, Sapienza University, Rome, Italy.
Background: Many patients with X-linked agammaglobulinemia (XLA) nowadays have reached adulthood, as well as their sisters, possibly carriers of a deleterious Bruton tyrosine kinase variant. Studies on motherhood outcomes in families with XLA are lacking.
Objective: We sought to investigate adherence to carrier status screening, interest in preconception and prenatal genetic counseling, and reproductive decisions in relatives with XLA.
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