Single-photon nonlinearity, namely, the change in the response of the system as the result of the interaction with a single photon, is generally considered an inherent property of a single quantum emitter. Although the dependence on the number of emitters is well understood for the case of two-level systems, deterministic operations such as single-photon switching or photon-atom gates inherently require more complex level structures. Here, we theoretically consider single-photon switching in ensembles of emitters with a Λ-level scheme and show that the switching efficiency vanishes with the number of emitters. Interestingly, the mechanism behind this behavior is the quantum Zeno effect, manifested in a slowdown of the photon-controlled dynamics of the atomic ground states.
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http://dx.doi.org/10.1103/PhysRevLett.133.113601 | DOI Listing |
J Biomed Opt
October 2024
Privolzhsky Research Medical University, Institute of Experimental Oncology and Biomedical Technologies, Novgorod, Russia.
Significance: Autofluorescence characteristics of the reduced nicotinamide adenine dinucleotide and oxidized flavin cofactors are important for the evaluation of the metabolic status of the cells. The approaches that involve a detailed analysis of both spectral and time characteristics of the autofluorescence signals may provide additional insights into the biochemical processes in the cells and biological tissues and facilitate the transition of spectral fluorescence lifetime imaging into clinical applications.
Aim: We present the experiments on multispectral fluorescence lifetime imaging with a detailed analysis of the fluorescence decays and spectral profiles of the reduced nicotinamide adenine dinucleotide and oxidized flavin under a single excitation wavelength aimed at understanding whether the use of multispectral detection is helpful for metabolic imaging of cancer cells.
Phys Rev Lett
September 2024
AMOS and Department of Chemical Physics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Single-photon nonlinearity, namely, the change in the response of the system as the result of the interaction with a single photon, is generally considered an inherent property of a single quantum emitter. Although the dependence on the number of emitters is well understood for the case of two-level systems, deterministic operations such as single-photon switching or photon-atom gates inherently require more complex level structures. Here, we theoretically consider single-photon switching in ensembles of emitters with a Λ-level scheme and show that the switching efficiency vanishes with the number of emitters.
View Article and Find Full Text PDFJ Nucl Med
October 2024
Nuclear Medicine Division, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota;
Our objective is to explore quantitative imaging markers for early prediction of treatment response in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) undergoing [Lu]Lu-DOTATATE therapy. By doing so, we aim to enable timely switching to more effective therapies in order to prevent time-resource waste and minimize toxicities. Patients diagnosed with unresectable or metastatic, progressive, well-differentiated, receptor-positive GEP-NETs who received 4 sessions of [Lu]Lu-DOTATATE were retrospectively selected.
View Article and Find Full Text PDFNat Commun
August 2024
Center for Hybrid Quantum Networks (Hy-Q), Niels Bohr Institute, University of Copenhagen, DK-2100, Copenhagen Ø, Denmark.
Realizing a sensitive photon-number-dependent phase shift on a light beam is required both in classical and quantum photonics. It may lead to new applications for classical and quantum photonics machine learning or pave the way for realizing photon-photon gate operations. Nonlinear phase-shifts require efficient light-matter interaction, and recently quantum dots coupled to nanophotonic devices have enabled near-deterministic single-photon coupling.
View Article and Find Full Text PDFACS Nano
September 2024
U.S. Naval Research Laboratory, Washington, District of Columbia 20375, United States.
Quantum photonics promises significant advances in secure communications, metrology, sensing, and information processing/computation. Single-photon sources are fundamental to this endeavor. However, the lack of high-quality single photon sources remains a significant obstacle.
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