Polymerlike structures are ubiquitous in nature and synthetic materials. Their configurational and migration properties are often affected by crowded environments leading to nonthermal fluctuations. Here, we study an ideal Rouse chain in contact with a nonhomogeneous active bath, characterized by the presence of active self-propelled agents which exert time-correlated forces on the chain. By means of a coarse-graining procedure, we derive an effective evolution for the center of mass of the chain and show its tendency to migrate toward and preferentially localize in regions of high and low bath activity depending on the model parameters. In particular, we demonstrate that an active bath with nonuniform activity can be used to separate efficiently polymeric species with different lengths and/or connectivity.
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http://dx.doi.org/10.1103/PhysRevLett.133.118102 | DOI Listing |
Arthritis Rheumatol
January 2025
Division of Medicine, Department of Inflammation and Rare Diseases, UCL Centre for Rheumatology, University College London, London, NW3 2PF, UK.
Objective: Scleroderma is a life-threatening autoimmune disease characterized by inflammation, tissue remodelling, and fibrosis. This study aimed to investigate the expression and function of transglutaminase 2 (TGM2) in scleroderma skin and experimentally-induced dermal fibrosis to determine its potential role and therapeutic implications.
Methods: We performed immunohistochemistry on skin sections to assess TGM2 expression and localisation, and protein biochemistry of both SSc-derived and healthy control dermal fibroblasts to assess TGM2 expression, function and ECM deposition in the presence of a TGM2 and TGFβ neutralizing antibodies and a small molecule inhibitor of the TGFβRI kinase.
Angew Chem Int Ed Engl
January 2025
National University of Singapore, Dept of Diagnostic Radiology, SINGAPORE.
Mitophagy that disrupt mitochondrial membrane potential (MMP), represents a critical focus in pharmacology. However, the discovery and evaluation of MMP-disrupting drugs are often hampered using commercially available marker molecules that target similar or identical zones. These markers can significantly interfere with, obscure, or amplify the functional effects of MMP-targeting drugs, frequently leading to clinical failures.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
Institute of Applied Electrochemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029 PR China. Electronic address:
The electrochemical activation and partial oxidation of methane are highly attractive to enable the direct conversion in a sustainable and decentralized way. Herein, we report an electrochemical system in a non-diaphragm electrochemical bath to convert CH to CHOH and CHCHOH at room temperature, in which VO·HO as the anodic catalyst to activate CH and an aprotic ionic liquid [BMIM]BF as supporting electrolyte to control superoxide radicals (O) as the main active oxygen species generated on cathode. As a result, methanol and ethanol were identified as the liquid products, and the superior methanol Faraday efficiency (FE) of 32.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Department of Engineering, University of Exeter, Exeter EX4 4QF, UK.
A rapidly growing body of experimental evidence in the literature shows that the effects of humans interacting with vibrating structures, other humans, and their surrounding environment can be critical for reliable estimation of structural vibrations. The Interaction-based Vibration Serviceability Assessment framework (I-VSA) was proposed by the authors in 2017 to address this, taking into account human-structure dynamic interactions (HSI) to simulate the structural vibrations experienced by each occupant/pedestrian. The I-VSA method, however, had limited provisions to simulate simultaneously multiple modes of structure in HSI, to simulate human-human and human-environment interactions, and the movement pattern of the occupants/pedestrians.
View Article and Find Full Text PDFNutrients
December 2024
Department of Pharmacognosy, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400010 Cluj-Napoca, Romania.
Background/aim: L. () is an aromatic medicinal species with important nutraceutical potential, having rosmarinic acid (RA) as one of its main metabolites. The present study aims to evaluate the effects of an extract obtained from the leaves of this species and of its main metabolite in improving the streptozotocin-induced damage of hearts and aorta of diabetic rats.
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