Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/jamanetworkopen.2024.35857 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice.
Addict Neurosci
December 2024
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
The number of opioid overdose deaths has increased over the past several years, mainly driven by an increase in the availability of highly potent synthetic opioids, like fentanyl, in the un-regulated drug supply. Over the last few years, changes in the drug supply, and in particular the availability of counterfeit pills containing fentanyl, have made oral use of opioids a more common route of administration. Here, we used a drinking in the dark (DiD) paradigm to model oral fentanyl self-administration using increasing fentanyl concentrations in male and female mice over 5 weeks.
View Article and Find Full Text PDFOptimal allocation and application of water resources based on real water saving in a region with intensive human activity.
J Environ Manage
December 2024
State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin, China Institute of Water Resources and Hydropower Research, Beijing, 100038, PR China. Electronic address:
As water demand continues to grow, water resource management that only restricts water withdrawal can no longer ensure sustainable water use, especially in region with intensive human activities. In the water cycle of precipitation, runoff and evapotranspiration at the basin scale, only water evapotranspiration is the actual consumption of water. Water resource management that aims to control the total consumption within a basin is referred to as "real water saving," which can prevent the depletion of water resources.
View Article and Find Full Text PDFDiscovery of 6α-Thiazolylcarboxamidonaltrexamine Derivative (NTZ) as a Potent and Central Nervous System Penetrant Opioid Receptor Modulator with Drug-like Properties for Potential Treatment of Opioid Use Disorder.
ACS Pharmacol Transl Sci
December 2024
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, Virginia23298, United States.
The development of highly potent and selective μ opioid receptor (MOR) modulators with favorable drug-like properties has always been a focus in the opioid domain. Our previous efforts led to the discovery of a lead compound designated as NAT, a potent centrally acting MOR modulator. However, the fact that NAT precipitated considerable withdrawal effects at higher doses largely impaired its further development.
View Article and Find Full Text PDFSynaptic Structure and Transcriptomic Profiling of Reward and Sensory Brain Areas in Male Mice of Fentanyl Addiction.
Subst Abuse Rehabil
December 2024
The Joint Innovation Center for Health & Medicine, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, People's Republic of China.
Background: Opioid-based medications are powerful analgesics commonly prescribed for pain management, but they are also highly addictive. The over-prescription of opioids analgesics has triggered current opioid crisis, which now has expanded to heroin and illicit synthetic opioids like fentanyl and its analogues. The side effects of fentanyl abuse have been well recognized, yet the underlying molecular adaptations across brain regions upon fentanyl exposure remain elusive.
View Article and Find Full Text PDFNew insight in psychotic cannabis withdrawal: case series and brief overview.
Riv Psichiatr
December 2024
San Luigi Gonzaga Hospital, University of Turin, Orbassano (Torino), Italy - Department of Neurosciences "Rita Levi Montalcini", University of Turin, Italy.
Background: Cannabis is the most used recreational drug worldwide. Its use can increase the risk of developing psychotic disorders and exacerbate their course. However, little is known about the relationship between psychosis and withdrawal and the literature is still scarce.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!