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- a large-scale dataset of 3D medical shapes for computer vision.
Biomed Tech (Berl)
December 2024
Institute for Artificial Intelligence in Medicine (IKIM), University Hospital Essen (AöR), Essen, Germany.
Objectives: The shape is commonly used to describe the objects. State-of-the-art algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from the growing popularity of ShapeNet (51,300 models) and Princeton ModelNet (127,915 models).
View Article and Find Full Text PDFFrom data to discovery: Neuroinformatics in understanding Alzheimer's disease.
J Biosci
December 2024
Bioinformatics Program, University of Arkansas for Medical Sciences, University of Arkansas at Little Rock, Little Rock, AR, USA.
Neuroinformatics, an interdisciplinary field integrating neuroscience and informatics, plays a crucial role in understanding the complexities of the brain and neurological diseases such as Alzheimer's disease (AD). This review explores the applications, databases, and tools used in neuroinformatics, focusing on their role in AD research. Neuroinformatics facilitates data integration, analysis, and modeling, enabling researchers to unravel the underlying mechanisms of AD pathology.
View Article and Find Full Text PDFNon-parametric full cross mapping (NFCM): a highly-stable measure for causal brain network and a pilot application.
J Neural Eng
December 2024
Lanzhou University, No. 222 South Tianshui Road, Lanzhou, Gansu, 730000, CHINA.
Objective: Measuring causal brain network from neurophysiological signals has recently attracted much attention in the field of neuroinformatics. Traditional data-driven algorithms are computationally time-consuming and unstable due to parameter settings.
Approach: To resolve these limits, we proposed a novel parameter-free technique, called "non-parametric full cross mapping (NFCM)".
Neonatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography.
eNeuro
December 2024
Program in Neuroscience and Mental Health, SickKids Research Institute, Toronto, Ontario M5G 1L7, Canada
Preterm infants are at risk for brain injury and neurodevelopmental impairment due, in part, to white matter injury following chronic hypoxia exposure. However, the precise molecular mechanisms by which neonatal hypoxia disrupts early neurodevelopment are poorly understood. Here, we constructed a brain-wide map of the regenerative response to newborn brain injury using high-resolution imaging-based spatial transcriptomics to analyze over 800,000 cells in a mouse model of chronic neonatal hypoxia.
View Article and Find Full Text PDFData-driven analysis identifies novel modulation of social behavior in female mice witnessing chronic social defeat stress.
Biol Psychiatry
December 2024
Department of Psychology, McGill University, Montréal, QC, Canada; Ludmer Centre for Neuroinformatics and Mental Health, Montréal, QC, Canada. Electronic address:
Background: Chronic social defeat stress is a widely used depression model in male mice. Several proposed adaptations extend this model to females with variable, often marginal effects. We examine if the widely used male-defined metrics of stress are suboptimal in females witnessing defeat.
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