AI Article Synopsis
- Dielectrophoresis (DEP) is a technique used for manipulating polarized particles using electric fields, allowing for precise control without direct contact.
- The paper reviews recent advancements in DEP for separating and manipulating microparticles and biological cells, focusing on different chip designs for DC-DEP and AC-DEP methods.
- It also explores functional customizations of DEP systems for tasks like separation and purification, aiming to inspire the development of innovative high-throughput micro/nano platforms for real-world applications.
Article Abstract
Dielectrophoresis (DEP) is an advanced microfluidic manipulation technique that is based on the interaction of polarized particles with the spatial gradient of a non-uniform electric field to achieve non-contact and highly selective manipulation of particles. In recent years, DEP has made remarkable progress in the field of microfluidics, and it has gradually transitioned from laboratory-scale research to high-throughput manipulation in practical applications. This paper reviews the recent advances in dielectric manipulation and separation of microparticles and biological cells and discusses in detail the design of chip structures for the two main methods, direct current dielectrophoresis (DC-DEP) and alternating current dielectrophoresis (AC-DEP). The working principles, technical implementation details, and other improved designs of electrode-based and insulator-based chips are summarized. Functional customization of DEP systems with specific capabilities, including separation, capture, purification, aggregation, and assembly of particles and cells, is then performed. The aim of this paper is to provide new ideas for the design of novel DEP micro/nano platforms with the desired high throughput for further development in practical applications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11429840 | PMC |
| http://dx.doi.org/10.3390/bios14090417 | DOI Listing |
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