In recent years, the interest in medical monitoring for human health has been rapidly increasing due to widespread concern. Hydrogels are widely used in medical monitoring and other fields due to their excellent mechanical properties, electrical conductivity and adhesion. However, some of the non-degradable materials in hydrogels may cause some environmental damage and resource waste. Therefore, organic renewable natural polymers with excellent properties of biocompatibility, biodegradability, low cost and non-toxicity are expected to serve as an alternative to those non-degradable materials, and also provide a broad application prospect for the development of natural-polymer-based hydrogels as flexible electronic devices. This paper reviews the progress of research on many different types of natural-polymer-based hydrogels such as proteins and polysaccharides. The applications of natural-polymer-based hydrogels in body movement detection and biomedical monitoring are then discussed. Finally, the present challenges and future prospects of natural polymer-based hydrogels are summarized.
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http://dx.doi.org/10.3390/bios14090415 | DOI Listing |
Acta Biomater
March 2025
Department of Chemistry in Pharmaceutical Sciences, School of Pharmacy, Institute Hospital 12 de Octubre (imas12), Universidad Complutense de Madrid (UCM), 28040, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid 28029, Spain. Electronic address:
In the present era, the treatment of skin-infected wounds and their associated inflammation constitutes a significant challenge. These infections have the potential to impede the healing process and become a life-threatening pathology, particularly due to the rise of bacterial resistance. Hydrogels could successfully address this issue due to their unique capabilities and versatility.
View Article and Find Full Text PDFInt J Biol Macromol
February 2025
Shandong Provincial Engineering Research Center of Novel Pharmaceutical Excipients and Controlled Release Preparations, College of Health & Medicine, Dezhou University, Dezhou, China. Electronic address:
Silk Fibroin (SF) hydrogels are easy to functionalize and possess biocompatibility, making them highly promising for the development of flexible electronic devices and wearable equipment. However, fabricating SF-based hydrogels with multiple functions such as low hysteresis, self-adhesion, and high elasticity, while constructing flexible wearable electronic devices with high sensitivity and fidelity, remains a challenge to date. To address these issues, this work reports a one-step preparation of a fully polymer-based triple-network hydrogel through precursor solution pH pre-regulation, with polyacrylamide (PAM) as a brittle network, methyl cellulose (MC) as a tough network, and SF as a zwitterionic macromolecule.
View Article and Find Full Text PDFChem Bio Eng
December 2024
National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, Nanjing 210093, China.
The liver's role in metabolism, detoxification, and immune regulation underscores the urgency of addressing liver diseases, which claim millions of lives annually. Due to donor shortages in liver transplantation, liver tissue engineering (LTE) offers a promising alternative. Hydrogels, with their biocompatibility and ability to mimic the liver's extracellular matrix (ECM), support cell survival and function in LTE.
View Article and Find Full Text PDFAdv Mater
February 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
Despite advancements in biomimetic mineralization techniques, the repair of large-scale bone defects remains a significant challenge. Inspired by the bone formation process, a multidimensional biomimetic cascade strategy is developed by replicating the biomineralization cascade, emulating the hierarchical structure of bone, and biomimicking its biological functions for efficient bone regeneration. This strategy involves the photocrosslinking of sodium methacrylate carboxymethyl cellulose-stabilized amorphous magnesium-calcium phosphate with methacrylate-modified type I collagen to create a self-mineralizing hydrogel.
View Article and Find Full Text PDFJ Colloid Interface Sci
May 2025
Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
Multilayered natural polymer-based hydrogels possess excellent properties and hold great promise for applications in materials science, food technology, and biomedicine. However, constructing such complex structures remains challenging due to difficulties in achieving precise control and ensuring operational convenience. To address these challenges, we propose a facile strategy based on a diffusion reaction combined with substrate effect to construct onion-like multilayer natural polymer-based hydrogels, using calcium alginate hydrogels as a model system.
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