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Resistive pulse analysis of chiral amino acids utilizing metal-amino acid crystallization differences.
Analyst
May 2024
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
Here, we report a proof-of-concept resistive pulse method for analyzing chiral amino acids utilizing metal-amino acid crystallization differences. This method involves introducing an amino acid sample solution into a micropipette through a pressure-driven flow. The sample then mixes with a metal ion solution inside the pipette, forming metal-amino acid crystals.
View Article and Find Full Text PDFCharacterization of an artificial intelligence model for ranking static images of blastocyst stage embryos.
Fertil Steril
March 2022
Ovation Fertility, Austin, Texas.
Objective: To perform a series of analyses characterizing an artificial intelligence (AI) model for ranking blastocyst-stage embryos. The primary objective was to evaluate the benefit of the model for predicting clinical pregnancy, whereas the secondary objective was to identify limitations that may impact clinical use.
Design: Retrospective study.
Nanoelectronic Coating Enabled Versatile Multifunctional Neural Probes.
Nano Lett
August 2017
Department of Biomedical Engineering, ‡Department of Physics, and §Center for Learning and Memory, Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, United States.
Brain function can be best studied by simultaneous measurements and modulation of the multifaceted signaling at the cellular scale. Extensive efforts have been made to develop multifunctional neural probes, typically involving highly specialized fabrication processes. Here, we report a novel multifunctional neural probe platform realized by applying ultrathin nanoelectronic coating (NEC) on the surfaces of conventional microscale devices such as optical fibers and micropipettes.
View Article and Find Full Text PDFOn intrinsic stress fiber contractile forces in semilunar heart valve interstitial cells using a continuum mixture model.
J Mech Behav Biomed Mater
February 2016
Center for Cardiovascular Simulation, Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, The University of Texas at Austin, 201 East 24th Street, POB 5.236, 1 University Station C0200, Austin, TX 78712, USA. Electronic address:
Heart valve interstitial cells (VICs) play a critical role in the maintenance and pathophysiology of heart valve tissues. Normally quiescent in the adult, VICs can become activated in periods of growth and disease. When activated, VICs exhibit increased levels of cytokines and extracellular matrix (ECM) synthesis, and upregulated expression and strong contraction of α-smooth muscle actin (α-SMA) fibers.
View Article and Find Full Text PDFParallel microchannel-based measurements of individual erythrocyte areas and volumes.
Biophys J
January 2003
Visual and Circulatory Biophysics Laboratory, Department of Biomedical Engineering, Boston University, Massachusetts 02215, USA.
We describe a microchannel device which utilizes a novel approach to obtain area and volume measurements on many individual red blood cells. Red cells are aspirated into the microchannels much as a single red blood cell is aspirated into a micropipette. Inasmuch as there are thousands of identical microchannels with defined geometry, data for many individual red cells can be rapidly acquired, and the fundamental heterogeneity of cell membrane biophysics can be analyzed.
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