AI Article Synopsis
- Immunosuppressive therapy after kidney transplant increases the risk of opportunistic infections like pneumonia caused by PJP.
- Belatacept, a drug used to prevent T cell activation, may heighten the risk of developing PJP in kidney transplant patients.
- Two cases are presented where patients with PJP were diagnosed during an evaluation for unexplained fever, despite lacking common clinical signs, highlighting the need to consider PJP even without typical symptoms.
Article Abstract
Immunosuppressive therapy after kidney transplantation is associated with an increased risk for the development of opportunistic infections, such as pneumonia (PJP). Belatacept, a selective costimulatory blocker that prevents T cell activation, was previously suggested to be a potential risk factor for PJP development in kidney transplant recipients. We present 2 cases of kidney transplant patients with PJP discovered unexpectedly during a diagnostic work-up for fever of unknown origin. Both patients lacked typical clinical findings such as hypoxia, ground-glass pattern on computed tomography, or suggestive biochemical alterations such as high lactate dehydrogenase levels or hypercalcemia. PJP should therefore be included in the differential diagnosis when evaluating fever in kidney transplant recipients receiving belatacept, even in the absence of typical pulmonary and laboratory findings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424793 | PMC |
| http://dx.doi.org/10.1016/j.xkme.2024.100891 | DOI Listing |
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