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Indolelactic acid as a potential metabolic biomarker for diagnosing gout. | LitMetric

Indolelactic acid as a potential metabolic biomarker for diagnosing gout.

Exp Ther Med

Department of Rheumatology and Immunology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.

Published: November 2024

AI Article Synopsis

  • Gout is a complex disease caused by the buildup of monosodium urate crystals in joints, and its causes are not fully understood, highlighting the need for new biomarkers for early detection and diagnosis.
  • A study analyzed serum samples from 47 gout patients and 49 healthy individuals using advanced metabolomics techniques, identifying 186 metabolites that significantly differed between the two groups, with 156 upregulated and 30 downregulated in gout patients.
  • Among the findings, indolelactic acid (ILA) emerged as a potential biomarker for gout, and the study suggested that pathways related to D-glutamine and D-glutamate metabolism may play crucial roles in the disease's development.

Article Abstract

Gout is a heterogeneous disease caused by the deposition of monosodium urate crystals in joints, but its pathogenesis is currently poorly understood. The discovery of novel biomarkers is necessary for the early detection and diagnosis of gout. The present study aimed to characterize the metabolic profile of patients with gout using metabolomics, and to uncover the underlying pathological mechanisms leading to gout development. Serum samples were collected from 49 healthy participants and 47 patients with gout. Using ultra-high-performance liquid chromatography Orbitrap Exploris mass spectrometer non-target metabolomics technology, with a variable importance in the projection >1 and a false discovery rate adjusted P<0.05 was used, while a biomarker panel was screened using receiver operating characteristic (ROC) analysis. The potential differentially expressed markers related to gout were identified by ROC analysis, and the erythrocyte sedimentation rate, uric acid, alanine transaminase, aspartate aminotransferase, creatinine, triglyceride, total cholesterol, high-density lipoprotein and low-density lipoprotein levels were significantly different in the group of patients with gout compared with those in healthy individuals. A total of 186 differentially expressed metabolites were identified, with 156 differential metabolites upregulated and 30 downregulated in the patients with gout compared with healthy individuals. Pathway analysis demonstrated that D-glutamine and D-glutamate metabolism may serve key roles in gout. Compared with healthy people, the indolelactic acid (ILA) level of patients with gout was significantly higher. ILA may serve as a potential biomarker for the diagnosis of gout and could be used to detect or predict gout progression in the future.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11425795PMC
http://dx.doi.org/10.3892/etm.2024.12717DOI Listing

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