Acute poisoning is a prevalent health issue, particularly among children, due to their natural curiosity and tendency to explore. This cross-sectional study aimed to evaluate the characteristics, causes, clinical presentation, and outcomes of acute intoxication in children at Damietta General Hospital, Egypt. We included 106 pediatric patients (aged under 18 years) with a clear history or clinical signs of acute poisoning. Data collection encompassed sociodemographic information, type of poison, mode of poisoning, and clinical outcomes. Poison Severity Score (PSS) was employed to assess the severity. The most affected age group was preschool children (3-6 years), accounting for 41.5 % of cases, with males representing 52.8 %. Accidental poisoning constituted 83 % of cases, with household cleaning products (34 %) and petroleum products (18.9 %) being the most common toxic agents. Clinical outcomes revealed that 33 % of patients experienced morbidity, with electrolyte imbalances being the most prevalent complication. The overall cure rate was 94.3 %, while the mortality rate was 5.7 %. This study highlights the significance of parental education and preventive measures, especially in rural areas, to reduce the risk of pediatric poisoning. The PSS proved useful in guiding clinical care, supporting its further use in pediatric toxicology settings.
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http://dx.doi.org/10.1016/j.toxrep.2024.101735 | DOI Listing |
Arch Dis Child
January 2025
Pediatric Emergency Department, Cruces University Hospital Paediatric Emergencies, Barakaldo, Spain
Introduction: Although the administration of activated charcoal (AC) is considered safe, the associated risk of pulmonary aspiration explains certain reluctance of physicians to use this procedure. The objective of this study was to analyse the rate of pulmonary aspiration in children receiving AC after accidental ingestion of a toxic substance.
Methods: We carried out a substudy of a multicentre prospective registry-based cohort study including children presenting with acute poisoning to 58 paediatric emergency department (EDs) members of the Spanish Society of Pediatric Emergency Medicine between 2008 and 2022 on certain previously designated days.
Aust Vet J
January 2025
Melbourne Veterinary School, University of Melbourne, Werribee, Victoria, Australia.
Background: PAPP is widely used in Australia as a potent vertebrate bait, with potential for off-target ingestion and poisoning in domestic dogs. Whilst toxicosis and resulting methaemoglobinaemia is anecdotally known to occur, this is the first description in the literature. This study reports thirteen clinical cases of suspected Para-aminopropiophenone (PAPP) toxicity in dogs, with the aim of describing clinical presentation and current management of toxicosis in this species.
View Article and Find Full Text PDFPlants (Basel)
January 2025
Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
The aim of our research was to understand the impact of ochratoxin A (OTA) exposure on various physiological and behavioral aspects in adult Wistar rats, and to evaluate the efficacy of a essential oil (EOC) treatment in restoring the damage caused by this toxin. The essential oils were extracted by hydrodistillation, a yield of 12.70% was obtained for EOC, and the GC-MS characterization of this essential oil revealed that its principal major components are eugenol (80.
View Article and Find Full Text PDFTaiwan J Obstet Gynecol
January 2025
Department of Emergency Medicine, MacKay Memorial Hospital, Taipei 10449, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; Toxicology Division, Department of Emergency Medicine, MacKay Memorial Hospital, Taipei 10449, Taiwan; Department of Nursing, Yuanpei University of Medical Technology, Hsinchu, Taiwan; MacKay Junior College of Medicine Nursing and Management, Taipei, Taiwan. Electronic address:
Objective: Bongkrekic acid (BKA) is a life-threatening toxin linked to foodborne illnesses. Herein, we report two fatalities among 33 patients who ingested BKA in March 2024, East Taipei, Taiwan.
Case Report: Our first case involved a 40-year-old female who presented with nausea, vomiting, and diarrhea after consuming wet rice noodles.
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