AI Article Synopsis
- In-58, a peptide derived from indolicidin, exhibits strong antibacterial effects with lower toxicity towards mammalian cells, unlike its precursor.
- The peptide demonstrates significant antifungal activity against human pathogens, effectively inhibiting their growth without negatively interacting with existing antifungal medications.
- Experimental results suggest that In-58 disrupts fungal cell wall integrity and DNA interaction, while also showing effectiveness in an infection model with low toxicity, indicating its potential use as a new treatment for sporotrichosis.
Article Abstract
In-58, a peptide derived from indolicidin, shows extraordinary antibacterial activity and lower toxicity than indolicidin toward mammalian cells. Here, we investigated the antifungal activity of In-58 against the human pathogen and . In-58 markedly inhibited the growth of isolates in microdilution assays and showed no antagonism with any tested antifungal agent (itraconazole, terbinafine or amphotericin B). Scanning electron microscopy and propidium iodide staining indicated that In-58 alters the cell wall integrity and interacts with DNA, leading to disruption of in a dose-dependent manner. In , the mitochondrial membrane potential decreased and reactive oxygen species increased after treatment with In-58. experiments in the (greater wax moth) larval infection model revealed the effectiveness of In-58 against infection with low toxicity. Our results indicate that In-58 possesses remarkable antifungal activity against and . It has potential as a novel drug for the treatment of sporotrichosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424419 | PMC |
| http://dx.doi.org/10.3389/fmed.2024.1458951 | DOI Listing |
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