AI Article Synopsis
- Community-wide mass drug administration (cMDA) is an effective but expensive method for controlling soil-transmitted helminths (STH), and understanding STH distribution can help create cheaper policies.
- The study analyzes data from the Geshiyaro project, using egg count data to determine Ascaris lumbricoides infection rates and parasite aggregation.
- Findings indicate that fewer individuals carry the majority of parasites as the overall infection rate in the community drops, suggesting a targeted approach for repeated treatments could be beneficial.
Article Abstract
Background: Community-wide mass drug administration (cMDA) is known as an effective, albeit costly, control strategy for soil-transmitted helminth (STH) parasites. A better understanding of STH aggregation after many rounds of cMDA could help shape more cost-effective policies.
Methods: This analysis uses data from the Geshiyaro project, aiming to break STH transmission by cMDA and water, sanitation and hygiene interventions. Ascaris lumbricoides infection prevalence is derived from egg count data and parasite aggregation is obtained by fitting a negative binomial distribution to the frequency distribution of faecal egg counts.
Results: The relationship between parasite dispersion and infection prevalence is approximately linear. Parasite aggregation increases as infection prevalence decreases.
Conclusions: A minority of individuals carry most parasites as prevalence decreases in the community. These individuals could be selectively targeted for repeated treatment.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638107 | PMC |
| http://dx.doi.org/10.1093/trstmh/trae059 | DOI Listing |
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