The aim of this study was to explore how medical resources and vaccine coverage relate to infant mortality rate (IMR) and under-five mortality rate (U-5MR), which are both key national health indicators. This longitudinal study was based on panel data from the national level of 200 countries. Data from 1990 to 2021 were grouped into seven regions based on geographic and epidemiological similarities. Regarding correlation, the high-income region showed a different trend from that shown by other regions. Health expenditure was positively associated with IMR and U-5MR globally. Number of medical doctors per 1,000 people was negatively associated with IMR and U-5MR globally. Hepatitis type B (HBV) and measles, first dose (MCV) were negatively associated with IMR and HBV, MCV, and Bacillus Calmette-Guérin were negatively associated with U-5MR globally. In quadratic regression, the correlation between the number of doctors and mortality stabilizes or plateaus at approximately four individuals. Overall vaccine coverage was positively correlated with mortality up to a certain threshold, beyond which it became negatively correlated. A higher number of doctors was consistently associated with decreased mortality, regardless of location, while other factors varied by region. Our study findings highlight the importance of implementing global strategies that are specific to each region's characteristics to reduce IMR and U-5MR.
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http://dx.doi.org/10.1177/27551938241284250 | DOI Listing |
JACC Cardiovasc Interv
January 2025
Department of Cardiology of The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, China. Electronic address:
Background: The association between coronary microcirculation and clinical outcomes in patients with intermediate stenosis remains unclear.
Objectives: The aim of this study was to assess the prognostic significance of angiography-derived index of microcirculatory resistance (angio-IMR) in patients with intermediate coronary stenosis.
Methods: This post hoc analysis included 1,658 patients from the FLAVOUR (Fractional Flow Reserve and Intravascular Ultrasound for Clinical Outcomes in Patients with Intermediate Stenosis) trial, with angio-IMR measured in each vessel exhibiting intermediate stenosis.
ESC Heart Fail
January 2025
Division of Cardiology, Department of Medicine, Kindai University Faculty of Medicine, Osaka, Japan.
Aims: The Tpeak-Tend interval on electrocardiogram may be a predictor of worse outcomes in Takotsubo syndrome (TTS), but the mechanisms have not been fully determined. This study aimed to investigate the relationships between the corrected Tpeak-Tend (cTp-e) interval and coronary microvascular-dysfunction (CMD) assessed by the angiography-derived index of microvascular resistance (Angio-IMR) and the in-hospital prognosis in patients with TTS.
Methods And Results: We retrospectively evaluated 111 consecutive patients admitted for TTS who underwent coronary angiography at Kindai University Hospital from October 2009 to July 2023.
Integr Med Res
March 2025
Institute of General Practice and Interprofessional Care, University Hospital Tübingen, Tübingen, Germany.
Traditional, complementary, and integrative medicine (TCIM) research encompasses a diverse range of health practices rooted in various cultural, philosophical, and historical frameworks. As global interest in conducting research in this field grows, the need for rigorous research to support the integration of evidence-based TCIM therapies into mainstream healthcare has become essential. Data sharing is critical to advancing TCIM research by enhancing reproducibility, fostering interdisciplinary collaboration, promoting ethical practices, and addressing global health challenges.
View Article and Find Full Text PDFGeroscience
January 2025
Buck Institute for Research On Aging, Novato, CA, 94945, USA.
Cells are subjected to dynamic mechanical environments which impart forces and induce cellular responses. In age-related conditions like pulmonary fibrosis, there is both an increase in tissue stiffness and an accumulation of senescent cells. While senescent cells produce a senescence-associated secretory phenotype (SASP), the impact of physical stimuli on both cellular senescence and the SASP is not well understood.
View Article and Find Full Text PDFMalar J
January 2025
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
Background: In moderate-to-high malaria transmission regions, the World Health Organization recommends intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) alongside insecticide-treated bed nets to reduce the adverse consequences of pregnancy-associated malaria. Due to high-grade Plasmodium falciparum resistance to SP, novel treatment regimens need to be evaluated for IPTp, but these increase pill burden and treatment days. The present qualitative study assessed the acceptability of IPTp-SP plus dihydroartemisinin-piperaquine (DP) in Papua New Guinea, where IPTp-SP was implemented in 2009.
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