AI Article Synopsis
- - Receptor tyrosine kinases (RTKs) play crucial roles in cell functions like growth and differentiation, and when their signaling is disrupted, it can lead to tumors and make treatments less effective.
- - This study analyzed gene expressions of specific RTKs (TAM, RON, EPHA2, and MET) in breast cancer tissues using qPCR, focusing on how these expressions relate to clinical data.
- - Findings suggest that the expression of TYRO3, MET, and EPHA2 is associated with factors like tumor subtype, patient age, and lifestyle choices such as smoking and obesity, indicating their potential significance in breast cancer.
Article Abstract
Receptor tyrosine kinases (RTKs) are involved in cell growth, motility, and differentiation. Deregulation of RTKs signaling is associated with tumor development and therapy resistance. Potential RTKs like TAM (TYRO3, AXL, MERTK), RON, EPH, and MET have been evaluated in many cancers like lung, prostate, and colorectal, but little is known in breast tumors. In this study, 51 luminal breast cancer tissue and 8 triple negative breast cancer (TNBC) subtypes were evaluated by qPCR for the expression of TAM, RON, EPHA2, and MET genes. Statistical analysis was performed to determine the correlation to clinical data. TYRO3 is related to tumor subtype and stage, patient's age, smoking habits, and obesity. MET expression is correlated to EPHA2 and TAM gene expression. EPHA2 expression is also related to aging and smoking habits. The expression levels of the TAM and EPHA2 genes seem to play an important role in breast cancer, being also influenced by the patient's lifestyle.
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| http://dx.doi.org/10.1002/cbf.4128 | DOI Listing |
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