AI Article Synopsis
- The hypothalamic-pituitary-gonadal axis is key to regulating reproduction, with kisspeptin acting as a crucial chemical mediator that influences this process.
- Kisspeptin not only aids in reproductive function by stimulating hormone release but also helps maintain energy balance, which is essential for optimal reproductive health.
- More research is needed to fully understand the mechanisms of kisspeptin in reproduction, including its signaling pathways, which could offer insights for infertility treatments and contraceptive development.
Article Abstract
The hypothalamic-pituitary-gonadal axis, which regulates steroidogenesis and germ cell formation, closely regulates the reproduction process. Nonetheless, other chemical mediators, such as kisspeptin, influence this axis. Kisspeptin is a hypothalamic neuropeptide that modulates the function of this axis and also plays a central role in energy balance. The present study reviews the impact and associated mechanisms of kisspeptin on male and female reproduction based on available evidence in the literature. Kisspeptin and its neurons exert anorexigenic activity, thus maintaining adequate energy balance for optimal reproductive function. Also, they stimulate the release of GnRH, resulting in the optimal performance of gonadal physiological processes viz. production of steroid sex hormones and germ cells. However, studies linking kisspeptin to reproduction are yet scanty. Hence, studies exploring the upstream and downstream signaling pathways activated by kisspeptin concerning reproduction in an attempt to better understand the associated mechanisms of the regulatory activities of kisspeptin on reproduction are recommended. In addition, potential factors that may modulate kisspeptin activities may be useful in the management of infertility and perhaps, in the development of contraceptives for those who do not intend to achieve conception.
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| http://dx.doi.org/10.1007/s12013-024-01537-w | DOI Listing |
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