Redefining at-risk patients undergoiong pancreaticoduodenectomy: Impact of socioeconomic factors including Area Deprivation Index and distance traveled.

Background: The Whipple procedure for pancreatic adenocarcinoma frequently is referred to surgeons at high-volume centers, which requires that patients travel long distances, potentially impacting patient outcomes. Furthermore, patients with pancreatic cancer from underserved areas often have poor outcomes. There are limited data on Whipple outcomes on the basis of both socioeconomic and distance traveled.

Methods: This retrospective cohort study examined patients who underwent the Whipple procedure for pancreatic adenocarcinoma at a tertiary care center from 2019 to 2021. Patients who lived in areas with an Area Deprivation Index national percentile of >50% and ≥100 miles away from the care center were labeled as "at-risk" patients.

Results: Seventy-eight patients were included, with 22 (28.2%) patients determined to be at risk. The preoperative characteristics were comparable between the patients in the at-risk and standard-risk groups. Postoperatively, patients in the at-risk group were more likely to require reoperation (13.6% vs 0%; P = .020) and less likely to undergo adjuvant chemotherapy (73.2% vs 50%; P = .034) than patients in the standard-risk group; pathologic staging and frequency of previous use of neoadjuvant chemotherapy were not significantly different between the groups. At-risk status did not influence overall survival or recurrence rate.

Conclusions: Through the integration of distance traveled and Area Deprivation Index, we have redefined the characterization of at-risk patients with pancreatic adenocarcinoma, who are at greater risk of undergoing reoperation and not receiving adjuvant chemotherapy. By addressing these intersecting challenges, providers can mitigate disparities and improve the care of these patients with pancreatic adenocarcinoma.