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| http://dx.doi.org/10.1136/jitc-2024-010330 | DOI Listing |
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CT-based habitat radiomics for predicting treatment response to neoadjuvant chemoimmunotherapy in esophageal cancer patients.
Front Oncol
December 2024
Department of Thoracic Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Introduction: We used habitat radiomics as an innovative tumor biomarker to predict the outcome of neoadjuvant therapy for esophageal cancer.
Methods: This was a two-center retrospective clinical study in which pretreatment CT scans of 112 patients with esophageal cancer treated with neoadjuvant chemoimmunotherapy and surgery between November 2020 and July 2023 were retrospectively collected from two institutions. For training (n = 85) and external testing (n = 27), patients from both institutions were allocated.
CT-based delta-radiomics for predicting pathological response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma: a multicenter study.
BMC Med Imaging
December 2024
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Background: The study aimed to investigate the predictive value of delta-radiomics derived from computed tomography (CT) for pathological complete response (pCR) to neoadjuvant immunochemotherapy (NICT) among patients with esophageal squamous cell carcinoma (ESCC), helping clinicians determine whether to modify the neoadjuvant treatment strategy, proceed to surgery, or forgo surgery altogether.
Methods: A total of 140 ESCC patients from two institutions (Database 1 = 93; Database 2 = 47) who underwent NICT and surgery were retrospectively included in the study. The training set consisted of patients from Database 1, while the testing set included patients from Database 2.
Effect of Intravenous Contrast on CT Body Composition Measurements in Patients with Intraductal Papillary Mucinous Neoplasm.
Diagnostics (Basel)
November 2024
Department of Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center & Research Institute, 12902 USF Magnolia Drive, Tampa, FL 33612, USA.
Article Synopsis
- The study examines how different post-contrast phases in CT scans impact measurements of body composition, focusing on pancreatic tumors.
- A total of 278 patients were analyzed using an AI-based software that segmented body compartments during three phases of contrast: noncontrast, arterial, and venous.
- Findings indicate that while muscle and fat area measurements showed relatively smaller biases across phases, the Hounsfield units for skeletal muscle and intermuscular adipose tissue demonstrated larger biases, suggesting these factors should be accounted for in CT assessments.
Prediction of Neoadjuvant Chemoradiotherapy Sensitivity in Patients With Esophageal Squamous Cell Carcinoma Using CT-Based Radiomics Combined With Clinical Features.
Dose Response
November 2024
Shandong Medical Imaging and Radiotherapy Engineering Center (SMIREC), Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
For patients with resectable locally advanced esophageal squamous cell carcinoma (ESCC), the current standard treatment is neoadjuvant chemoradiotherapy (nCRT) plus radical surgery. This study aimed to establish a predictive model, based on computed tomography (CT) radiomics features and clinical parameters, to predict sensitivity to nCRT in patients with ESCC pre-treatment. The goal was to provide risk stratification and decision-making recommendations for clinical treatments and offer more valuable information for developing personalized therapies.
View Article and Find Full Text PDFSystemic immune-related spleen radiomics predict progression-free survival in patients with locally advanced cervical cancer underwent definitive chemoradiotherapy.
BMC Med Imaging
November 2024
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China.
Purpose: Systemic immunity is essential for driving therapeutically induced antitumor immune responses, and the spleen may reflect alterations in systemic immunity. This study aimed to evaluate the predictive value of contrast-enhanced CT-based spleen radiomics for progression-free survival (PFS) in patients with locally advanced cervical cancer (LACC) who underwent definitive chemoradiotherapy (dCRT). Additionally, we investigated the role of spleen radiomics features and changes in spleen volume in assessing systemic immunity.
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