AI Article Synopsis
- Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) are specialized junctions that connect mitochondria and the endoplasmic reticulum, playing a crucial role in essential cellular functions.
- MAMs regulate important processes like calcium levels, lipid metabolism, and inflammatory responses, which are vital for maintaining the cells' health.
- The review highlights how MAMs are linked to the development of ocular disorders like Diabetic Retinopathy, Age-related Macular Degeneration, and glaucoma, discussing both their structural roles and pathogenic mechanisms.
Article Abstract
The intricate interaction network necessary for essential physiological functions underscores the interdependence among eukaryotic cells. Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs), specialized junctions between mitochondria and the ER, were recently discovered. These junctions participate in various cellular processes, including calcium level regulation, lipid metabolism, mitochondrial integrity maintenance, autophagy, and inflammatory responses via modulating the structure and molecular composition of various cellular components. Therefore, MAMs contribute to the pathophysiology of numerous ocular disorders, including Diabetic Retinopathy (DR), Age-related Macular Degeneration (AMD) and glaucoma. In addition to providing a concise overview of the architectural and functional aspects of MAMs, this review explores the key pathogenetic pathways involving MAMs in the development of several ocular disorders.
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| http://dx.doi.org/10.1016/j.exer.2024.110110 | DOI Listing |
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