Glioblastoma (GBM) is driven by malignant neural stem-like cells that display extensive heterogeneity and phenotypic plasticity, which drive tumor progression and therapeutic resistance. Here, we show that the extracellular matrix-cell adhesion protein integrin-linked kinase (ILK) stimulates phenotypic plasticity and mesenchymal-like, invasive behavior in a murine GBM stem cell model. ILK is required for the interconversion of GBM stem cells between malignancy-associated glial-like states, and its loss produces cells that are unresponsive to multiple cell state transition cues. We further show that an ILK/STAT3 signaling pathway controls the plasticity that enables transition of GBM stem cells to an astrocyte-like state in vitro and in vivo. Finally, we find that ILK expression correlates with expression of STAT3-regulated proteins and protein signatures describing astrocyte-like and mesenchymal states in patient tumors. This work identifies ILK as a pivotal regulator of multiple malignancy-associated GBM phenotypes, including phenotypic plasticity and mesenchymal state.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.devcel.2024.09.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Microbial Biotic Associations Dominated Adaptability Differences of Dioecious Poplar Under Salt Stress.
Plant Cell Environ
January 2025
Key Laboratory of the State Forestry and Grassland Administration for the Cultivation of Forests in the Lower Reaches of the Yellow River, College of Forestry, Shandong Agricultural University, Tai'an, China.
How different stress responses by male and female plants are influenced by interactions with rhizosphere microbes remains unclear. In this study, we employed poplar as a dioecious model plant and quantified biotic associations between microorganisms to explore the relationship between microbial associations and plant adaptation. We propose a health index (HI) to comprehensively characterize the physiological characteristics and adaptive capacity of plants under stress.
View Article and Find Full Text PDFMarginal response of non-structural carbohydrates and increased biomass in a dominant shrub (Dasiphora fruticosa) to water table decline in a minerotrophic peatland.
Plant Biol (Stuttg)
January 2025
Key Laboratory of Geographical Processes and Ecological Security in Changbai Mountains, Ministry of Education, School of Geographical Sciences, Northeast Normal University, Changchun, China.
Assessing how dominant peatland species, such as Dasiphora fruticosa, adapt to water table decline is crucial to advance understanding of their growth and survival strategies. Currently, most studies have primarily focused on their growth and biomass, with limited knowledge on the response of non-structural carbohydrates (NSCs) and physiological adaptations of these woody plants under long-term drainage. This study assessed the response of photosynthesis and transpiration rates, biomass, and NSC concentrations (including soluble sugars and starch) in the leaves, stems, and roots of D.
View Article and Find Full Text PDFA Pollen-Based Assisted Migration for Rapid Forest Adaptation.
Glob Chang Biol
January 2025
Faculty of Forestry and Wood Sciences, Czech University of Life Sciences Prague, Prague, Czech Republic.
Climate change poses an unprecedented threat to forest ecosystems, necessitating innovative adaptation strategies. Traditional assisted migration approaches, while promising, face challenges related to environmental constraints, forestry practices, phytosanitary risks, economic barriers, and legal constraints. This has sparked debate within the scientific community, with some advocating for the broader implementation of assisted migration despite these limitations, while others emphasize the importance of local adaptation, which may not keep pace with the rapid rate of climate change.
View Article and Find Full Text PDFThe association between stent design and patient exercise intensity: structural coupling effects and hemodynamic analysis.
Front Bioeng Biotechnol
December 2024
School of Aeronautic Science and Engineering, Beihang University, Beijing, China.
Introduction: In-stent restenosis remains a significant challenge in coronary artery interventions. This study aims to explore the relationship between exercise intensity and stent design, focusing on the coupled response of the stent structure and hemodynamics at different exercise intensities.
Methods: A coupled balloon-stent-plaque-artery model and a fluid domain model reflecting structural deformation were developed to investigate the interaction between coronary stents and stenotic vessels, as well as their impact on hemodynamics.
The constrained-disorder principle defines the functions of systems in nature.
Front Netw Physiol
December 2024
Faculty of Medicine, Hadassah Medical Center, Hebrew University, Jerusalem, Israel.
The Constrained Disorder Principle (CDP) defines all systems in nature by their degree of inherent variability. Per the CDP, the intrinsic variability is mandatory for their proper function and is dynamically changed based on pressures. The CDP defines the boundaries of inherent variability as a mechanism for continuous adaptation to internal and external perturbations, enabling survival and function under dynamic conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!