AI Article Synopsis
- The enteric nervous system (ENS) is flexible and changes during its development, but how well it can repair itself is still not fully understood.
- Stavely and colleagues have discovered that enteric neurons can reconnect and restore function in damaged areas.
- The reinnervation process is guided by a system they refer to as the glial positioning system (GPS).
Article Abstract
While the enteric nervous system (ENS) is highly dynamic during development, the extent to which it is capable of repair remains unclear. In this issue of Neuron, Stavely et al. show that enteric neurons can reinnervate damaged regions to regain functionality using a glial positioning system (GPS) as their guide.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neuron.2024.08.023 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Design and synthesis of novel derivatives of bisepoxylignans as potent anti-inflammatory agents involves the modulation of the M1/M2 microglia phenotype via TLR4/NF-κB signaling pathway.
Eur J Med Chem
January 2025
State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Natural Products Research Center of Guizhou Province, Guiyang, 550014, China. Electronic address:
Bisepoxylignans have been reported to possess a variety of biological functions, especially in anti-inflammatory aspects. However, the bis-tetrahydrofuran scaffold restricts the type and position of substituents, which further limits the further optimization of their biological activity and druggability. Here, a series of novel derivative s of bisepoxylignans bearing 7H-pyrrolo[2,3-d]pyrimidin-4-amine and 1H-pyrazolo[3,4-d]pyrimidin-4-amine scaffolds were designed and synthesized by a scaffold hopping strategy.
View Article and Find Full Text PDFOverexpression of the inwardly rectifying potassium channel Kir4.1 or Kir4.1 Tyr9 Asp in Müller cells exerts neuroprotective effects in an experimental glaucoma model.
Neural Regen Res
November 2024
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institute of Brain Science, Fudan University, Shanghai, China.
Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells, which is involved in retinal ganglion cell apoptosis in glaucoma. Modulation of Kir4.
View Article and Find Full Text PDFDistinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headache.
J Headache Pain
November 2024
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.
Background: Post-traumatic headache (PTH) is a common comorbid symptom affecting at least one-third of patients with mild traumatic brain injury (mTBI). While neuroinflammation is known to contribute to the development of PTH, the cellular mechanisms in the trigeminal system crucial for understanding the pathogenesis of PTH remain unclear.
Methods: A non-invasive repetitive mTBI (4 times with a 24-h interval) was induced in male mice and effect of mTBI was tested on either bregma or pre-bregma position on the head.
Immunohistochemical Expression of GFAP in the Brain Astrocytes of Deceased Newborns Depending on the Postmortem Interval.
Bull Exp Biol Med
November 2024
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia.
Article Synopsis
- - The study investigates changes in astrocytes related to brain diseases by analyzing GFAP (glial fibrillary acidic protein) expression in brain tissue from deceased newborns, examining samples based on varying postmortem periods.
- - Tissue samples from 48 deceased newborns were categorized into 8 groups, and immunohistochemical analysis showed a decrease in GFAP+ staining areas, indicating a reduction in fibrotic astrocytes over time.
- - The findings highlight that postmortem changes in GFAP expression must be considered in tissue sampling for research and forensic diagnosis, as they can affect the differentiation from lifetime brain lesions.
Glial fibrillary acidic protein in Alzheimer's disease: a narrative review.
Brain Commun
November 2024
IRMB-PPC, INM, Univ Montpellier, CHU Montpellier, INSERM CNRS, Montpellier, France.
Astrocytes are fundamental in neural functioning and homeostasis in the central nervous system. These cells respond to injuries and pathological conditions through astrogliosis, a reactive process associated with neurodegenerative diseases such as Alzheimer's disease. This process is thought to begin in the early stages of these conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!