Editors' selections from the current scientific literature.
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Exploring Molecular Mechanisms of Liver Fibrosis.
Int J Mol Sci
January 2025
Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital Aachen, D-52074 Aachen, Germany.
Liver diseases, particularly metabolic dysfunction-associated steatotic liver disease (MASLD), have emerged as a major global health concern, affecting millions of individuals and leading to increased morbidity and mortality [...
View Article and Find Full Text PDFChronic rhinosinusitis with nasal polyps: Key considerations in the multidisciplinary team approach.
Clin Transl Allergy
January 2025
Department of ENT, University of Leuven, Leuven, Belgium.
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a recurrent inflammatory disease associated with several comorbidities and a significant disease burden for patients. Treatments include corticosteroids and sinonasal surgery, but these can be associated with the risk of adverse events and nasal polyp recurrence. Biologic treatments such as mepolizumab can be used as an add-on treatment and are effective at reducing surgery and corticosteroid use.
View Article and Find Full Text PDFResearch in compulsory drug detention centres in China: Characteristics and ethical considerations.
Glob Public Health
December 2025
Department of Community Health and Prevention, Drexel Dornsife School of Public Health, Philadelphia, PA, USA.
More than 500 centres in China hold over 300,000 individuals in what has been described by the United Nations as unethical and ineffective compulsory treatment and rehabilitation centres. Individuals in these centres face widespread human rights abuses, including lack of due process, forced labour, physical and sexual violence, and denial of healthcare. Because of the vulnerability of individuals in detention settings to abuse in research trials, ethical guidelines have required research to pose no more than minimal risk, to address the process of incarceration, and the health or well-being of detained individuals.
View Article and Find Full Text PDFReporting quality of animal research in journals that published the ARRIVE 1.0 or ARRIVE 2.0 guidelines: a cross-sectional analysis of 943 studies.
Cardiovasc Diagn Ther
December 2024
Editorial Office, AME Publishing Company, Hong Kong, China.
Background: The adherence to the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines across the journals that initially published the guidelines and if adherence has improved since the guidelines update, remains unknown. We aimed to quantify the level of adherence and analyze factors that might influence reporting quality among these journals.
Methods: This cross-sectional study retrospectively analyzed interventional animal experiments published in journals that released ARRIVE 1.
Peer reviewers' conflicts of interest in biomedical research: scoping review.
BMJ Evid Based Med
January 2025
Cochrane Denmark & Centre for Evidence-Based Medicine Odense (CEBMO), Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Background: Peer review may improve the quality of research manuscripts and aid in editorial decisions, but reviewers can have conflicts of interest that impact on their recommendations.
Objectives: The objective was to systematically map and describe the extent and nature of empirical research on peer reviewers' conflicts of interest in biomedical research.
Design: Scoping review METHODS: In this scoping review, we included studies investigating peer reviewers' conflicts of interest in journal manuscripts, theses and dissertations, conference abstracts, funding applications and clinical guidelines.
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