AI Article Synopsis
- Pial collaterals help protect against ischemic damage and improve outcomes for stroke patients, but the development process for these collaterals is not well understood.
- This research used advanced imaging techniques to reveal that pial collateral arteries form from the growth and connection of existing arterial tips during embryonic development, influenced by a specific receptor.
- Unlike coronary collateral arteries in the heart, the formation of brain collaterals does not rely on the Cxcr4 receptor, indicating different developmental mechanisms at play for each organ.
Article Abstract
Pial collaterals provide protection from ischemic damage and improve the prognosis of stroke patients. The origin or precise sequence of events underlying pial collateral development is unclear and has prevented clinicians from adapting new vascularization and regeneration therapies. We use genetic lineage tracing and intravital imaging of mouse brains at cellular resolution to show that during embryogenesis, pial collateral arteries develop from extension and anastomoses of pre-existing artery tips in a VegfR2-dependent manner. This process of artery tip extension occurs on pre-determined microvascular tracks. Our data demonstrate that an arterial receptor, Cxcr4, earlier shown to drive artery cell migration and coronary collateral development, is dispensable for the formation and maintenance of pial collateral arteries. Our study shows that collateral arteries of the brain are built by a mechanism distinct from that of the heart.
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| http://dx.doi.org/10.1016/j.celrep.2024.114771 | DOI Listing |
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