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Evaluation of Peri-Implantitis through Fourier-Transform Infrared Spectroscopy on Saliva.
J Proteome Res
January 2025
University of Santo Amaro (UNISA), Rua Isabel Schmidt 349, São Paulo 04743-030, Brazil.
Background: Peri-implantitis is characterized as a pathological change in the tissues around dental implants. Fourier-transform infrared spectroscopy (FTIR) provides molecular information from optical phenomena observed by the vibration of molecules, which is used in biological studies to characterize changes and serves as a form of diagnosis.
Aims: this case-control study evaluated the peri-implant disease by using FTIR spectroscopy with attenuated total reflectance in the fingerprint region.
Integrated transcriptomics and proteomics analysis of the impact of iodine‑125 in hepatocellular carcinoma.
Mol Med Rep
March 2025
The First Central Clinical School, Tianjin Medical University, Tianjin 300000, P.R. China.
Hepatocellular carcinoma (HCC) is a common cause of cancer‑related mortality and morbidity worldwide. While iodine‑125 (I) particle brachytherapy has been extensively used in the clinical treatment of various types of cancer, the precise mechanism underlying its effectiveness in treating HCC remains unclear. In the present study, MHCC‑97H cells were treated with I, after which, cell viability and proliferation were assessed using Cell Counting Kit‑8, 5‑ethynyl‑2'‑deoxyuridine and colony formation assays, cell invasion and migration were evaluated using wound healing and Transwell assays, and cell apoptosis was determined using flow cytometry.
View Article and Find Full Text PDFExploring novel drug targets for erectile dysfunction through plasma proteome with genome.
Sex Med
December 2024
Department of Urology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China.
Background: Currently, the treatment and prevention of erectile dysfunction (ED) remain highly challenging.
Aim: This study conducted a systematic druggable genome-wide Mendelian randomization (MR) analysis to identify potential therapeutic targets for ED.
Methods: A proteome-wide MR approach was employed to investigate the causal effects of plasma proteins on ED.
The Omics-Driven Machine Learning Path to Cost-Effective Precision Medicine in Chronic Kidney Disease.
Proteomics
January 2025
School of Public Health, University of Haifa, Haifa, Israel.
Chronic kidney disease (CKD) poses a significant and growing global health challenge, making early detection and slowing disease progression essential for improving patient outcomes. Traditional diagnostic methods such as glomerular filtration rate and proteinuria are insufficient to capture the complexity of CKD. In contrast, omics technologies have shed light on the molecular mechanisms of CKD, helping to identify biomarkers for disease assessment and management.
View Article and Find Full Text PDFTwo decades of advances in sequence-based prediction of MoRFs, disorder-to-order transitioning binding regions.
Expert Rev Proteomics
January 2025
Department of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.
Introduction: Molecular recognition features (MoRFs) are regions in protein sequences that undergo induced folding upon binding partner molecules. MoRFs are common in nature and can be predicted from sequences based on their distinctive sequence signatures.
Areas Covered: We overview twenty years of progress in the sequence-based prediction of MoRFs which resulted in the development of 25 predictors of MoRFs that interact with proteins, peptides and lipids.
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